江苏省2万例育龄妇女孕前TORCH筛查结果分析  

Primary screening of TORCH infection in pre-pregnant women:An analysis of 20000 cases in Jiangsu.

作　　者：刘启兰[1] 林宁[1] 王丽娟[1] 童建孙 张建伟[1] 何竞[1] 徐晓燕[1] 陈伟[1] 刘艳[1] 

机构地区：[1]江苏省计划生育科学技术研究所,南京210036

出　　处：《中国优生与遗传杂志》2008年第7期97-99,共3页Chinese Journal of Birth Health & Heredity

基　　金：江苏省出生缺陷干预工程资助项目(项目号JS2003-02)

摘　　要：目的了解孕前妇女TORCH感染情况,对筛查出的风疹病毒抗体阴性者,通过注射风疹疫苗,获得主动免疫后再怀孕,对弓形虫抗体阳性,巨细胞病毒,单纯疱疹病毒及其他病毒感染者,转诊到相关医疗单位进行治疗,以减少缺陷儿的出生。方法采用生物芯片技术对20000例孕前妇女的血清进行TORCH病原体IgM检测。结果TORCH-IgM总阳性1784例、阳性率8.92%,单项病原体感染1395例、阳性率6.98%,合并感染(两种以上病原体)389例、阳性率1.95%。总Tox-IgM阳性419例、阳性率2.09%,RuV-IgM阳性825例、阳性率4.13%,CMV-IgM阳性423例、阳性率2.12%,HSV-I-IgM阳性422例、阳性率2.11%,HSV-Ⅱ-IgM阳性233例、阳性率1.17%。结论孕前妇女TORCH检测对预防宫内感染和畸形胎儿出生,提高出生人口素质具有非常重要的意义,建议将TORCH检测作为孕前常规检查项目。Objective ： To understand the prevalence of TORCH infection in pre - pregnant women, so as to provide active immunotherapy to those with negative RV antibodies by RV vaccination, give pre - pregnancy treatment to those infected with TOX, CMV, HSV or other virus and to reduce the number of abnormal fetuses. Methods： Serum samples from 20 000 pre - pregnant women were deterrdined for TORCH special IgM antibodies by microarray technique. Results： The total positive rate of TORCH was 8. 92% （ 1784/ 20000）, while those of TOX, RV, CMV, HSV -Ⅰ and HSV -Ⅱ were 2.09% （419/20000）, 4. 13% （825/20000） , 2. 12% （423/ 20000） , 2. 11% （422/20000） and 1.17% （233/20000） , respectively. Conclusion： Pre - pregnancy examination for TORCH infection is of important significance for the prevention of intrauterine infection and abnormal fetuses, as well as for the improvement of the neonatal population quality.

关 键 词：TORCH-IGM 弓形虫 风疹病毒 巨细胞病毒 单纯疱疹病毒 

分 类 号：R173[医药卫生—妇幼卫生保健]