新型脱氧胆酸类手性不对称脲分子钳的设计合成  

Design and Synthesis of Novel Deoxycholic Acid-Based Chiral Molecular Tweezers Containing Unsymmetrically Disubstituted Urea Unit

作　　者：赵志刚[1] 刘兴利[1] 李晖[1] 唐晓丽[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,成都610041

出　　处：《有机化学》2008年第7期1233-1237,共5页Chinese Journal of Organic Chemistry

基　　金：四川省应用基础研究(No.04JY029-003-08);西南民族大学博士创新基金(No.08NBS002)资助项目

摘　　要：以刚性的脱氧胆酸甲酯为隔离基,在其3位连接苯甲酰基,12位连接手性不对称脲,设计合成了一类新型的手性分子钳.其结构均经1HNMR,IR,MS和元素分析确证,并且考察了其对中性分子和D/L-氨基酸甲酯的识别性能.实验结果表明,这类分子钳人工受体不仅对中性有机小分子具有良好的识别能力,而且对D/L-氨基酸甲酯亦具有优良的对映选择性识别性能.A novel type of chiral molecular tweezers has been designed and synthesized by linking benzoyl and chiral unsymmetrically disubstituted urea unit to 3-position and 12-position of rigid methyl deoxycholate. Their structures were confirmed by ^1H NMR, IR, MS spectra and elemental analyses. The recognition properties of these molecular tweezers for neutral molecules and D/L-amino acid methyl esters have been investigated. The results indicate that these molecular tweezers not only recognize neutral organic molecules well, but also have good enantioselectivity for D/L-amino acid methyl esters.

关 键 词：脱氧胆酸 分子钳 合成 手性不对称脲 

分 类 号：O621.3[理学—有机化学]