酸催化合成邻氨基苯甲酸正丁酯  

Catalytic Synthesis of n-Butyl 2-Aminobenzoate with Concentrated Sulfuric Acid

作　　者：吕晓玲[1] 陈建梅 宋峰 

机构地区：[1]江苏石油化工学院应用化学系,常州213016 [2]常州化工研究所,常州213001

出　　处：《江苏石油化工学院学报》1997年第3期42-46,共5页Journal of Jiangsu Institute of Petrochemical Technology

摘　　要：研究了合成邻氨基苯甲酸正丁酯的催化剂和工艺条件。结果表明，氯化氢对该酯化反应的催化作用甚小；浓硫酸对邻氨基苯甲酸及其盐酸盐都有良好的催化作用，但后者催化剂用量显著减少。采用正交设计确定了最佳反应条件，邻氨基苯甲酸盐酸盐、正丁醇和浓硫酸的摩尔比为1：6．6～7．0：0：38（邻氨基苯甲酸盐酸盐0．1mol），酯化时间为10h，酯化收率为36．3％。n - Butyl 2 - aminobenzoate was synthesized with a yield of 36. 8% under optimaloptimal conditions by using 2 - aminobenzoic acid hydrochloride and n - butyl alcohol as reactants, concentrated sulfuric acid as catalyzer. Some factors that affected the esterifications of 2- aminobenzoic acid catalyzed by concentrated sulfuric acid or hydrogen chloride and 2aminobenzoic acid hydrochloride catalyzed by concentrated sulfuric acid were discussed.

关 键 词：酸催化 酯化 邻氨基 苯甲酸盐酸盐 

分 类 号：O625.636[理学—有机化学] TQ246.37[理学—化学]