兴奋剂重组人促红细胞生成素及其类似物检测方法的研究进展  

Recent advances in the detection of recombinant human erythropoiesis and its analogs in doping control

作　　者：杨霞[1] 庞楠楠[1] 廖一平[1] 刘虎威[1] 

机构地区：[1]北京分子科学国家实验室北京大学化学与分子工程学院,北京100871

出　　处：《色谱》2008年第4期413-416,共4页Chinese Journal of Chromatography

基　　金：国家自然科学基金资助项目(No.20635001)

摘　　要：重组人促红细胞生成素(rhEPO)是一种激素类兴奋剂,近年来被滥用在一些耐力性比赛项目中。由于重组与内源性EPO的氨基酸序列相同,区别很小,并且在尿样或血样中的浓度低,代谢快,给检测带来了很大的难度。本文从直接方法和间接方法两个方面综述了近几年来兴奋剂rhEPO及其类似物检测的研究进展,并结合本小组的工作展望了rhEPO检测的发展方向。Recombinant human erythropoietin （rhEPO） is one of hormone dopings. In the recent years, it has been always misused in endurance competition sports. It is extremely difficult to discriminate between the natural endogenous erythropoietin （EPO） and recombinant exogenous hormone because they have identical amino acid sequences, and EPO has a relatively short half-life and very low concentration in blood or urine. In this paper, the research progress on the analysis and detection of rhEPO and its analogs by direct and indirect methods are reviewed. Future direction and prospects of the detection of rhEPO in doping control are discussed based on the research of our group.

关 键 词：重组人促红细胞生成素 兴奋剂 检测 直接方法 间接方法 综述 

分 类 号：O658[理学—分析化学]