染料木素自微乳在家兔体内的相对生物利用度研究  

Study on the Relative Bioavailability of Micro-emulsified Genistein in Rabbits

作　　者：杜先华[1] 牛欣[1] 冯前进[2] 徐荣廷[1] 杜红[1] 李海燕[1] 

机构地区：[1]北京中医药大学,北京100029 [2]山西中医学院,太原030024

出　　处：《中药新药与临床药理》2008年第4期278-280,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家“十五”科技攻关课题(2004BA721A46)

摘　　要：目的研究染料木素自微乳在家兔体内的药物动力学和相对生物利用度。方法家兔分别灌胃染料木素自微乳和染料木素CMC-Na混悬液,用HPLC法测定不同时间血浆样品中染料木素的浓度,绘制药-时曲线,计算药动学参数及相对生物利用度。结果染料木素自微乳和染料木素混悬液药-时曲线下面积(AUC0→10h)分别为(24.90±1.24)和(10.71±0.86)μg·h·mL-1,血药峰浓度(Cmax)分别为(4.02±0.20)和(0.99±0.04)μg·mL-1,达峰时间(Tmax)分别为2h和4h,染料木素自微乳较染料木素混悬液的相对生物利用度为232.49%。结论染料木素自微乳可显著提高染料木素的生物利用度。Objective To study the pharmaeokineties and the relative bioavailability of micro - emulsified genistein in rabbits. Methods Rabbits received gastric gavage of micro - emulsified genistein and CMC - Na suspension of genistein. Then the genistein content in rabbit plasma at different time was determined by HPLC, concentration -time curve was drafted, and the pharmacokinetic parameters and the relative bioavailability were calculated. Results The main parameters of micro - emulsified genistein and CMC - Na suspension of genistein were as follows： AUC0→10h being（24.90 ± 1.24） and（10. 71 ±0. 86） μg·h·mL^-1, Cmax being（4.02 ±0.20）and（0.99 ±0. 04） μg·h·mL^-1, Tmax being 2 h and 4 h, respectively. The relative bioavailability of micro - emulsified genistein was 232. 49 %. Conclusion Micro - emulsified genistein system can improve the bioavailability of genistein evidently.

关 键 词：染料木素自微乳 高效液相色谱法 药物动力学 相对生物利用度 

分 类 号：R285.5[医药卫生—中药学]