普贝生在过期妊娠促宫颈成熟中的效果评价  

CLINICAL EVALUATION OF PROPESS FOR CERVICAL RIPENING IN PROLONGED PREGNANCY

作　　者：于琳[1] 刘平[1] 刘淼[1] 王花平[1] 祝玉琴[1] 万晓莉[1] 

机构地区：[1]北京大学深圳医院妇产科,广东深圳518036

出　　处：《河北医科大学学报》2008年第4期541-543,共3页Journal of Hebei Medical University

摘　　要：目的探讨控释前列腺素栓剂普贝生(propess)用于过期妊娠促宫颈成熟的有效性及安全性。方法采用病例对照研究的方法,随机选择30例过期妊娠宫颈条件不成熟的初产妇使用普贝生为研究组,相同条件30例使用传统方法催产素促宫颈成熟为对照组,比较两组产妇的宫颈Bishop评分、分娩情况。结果研究组产妇用药后宫颈Bishop评分,24例≥2分,对照组5例≥2分,有显著性差异(P<0.05);研究组产妇用药至临产发动时间、分娩时间分别为(11.50±7.31)h、(12.40±3.52)h,对照组分别为(27.70±7.10)h、(11.80±3.60)h,用药至临产发动时间有显著性差异(P<0.05),两组总产程比较无显著性差异(P>0.05);研究组产妇的剖宫产率为40%,对照组为57%,两组比较有显著性差异(P<0.05);胎儿窘迫及新生儿窒息发生率无显著性差异。结论普贝生用于过期妊娠促宫颈成熟效果满意。Objective To evaluate the efficacy and safety of the controlled release of prostaglandin suppository--propess for cervical ripening in prolonged pregnancy. Methods A case-control study method was used, randomly selected 30 primiparas of cervical immature prolonged pregnancy as the study group ,in which propess was used, 30 cases of the same conditions as the control group in which oxytocin traditional method was used for cervical ripening. The maternal cervical Bishop score and maternity informations was compared between the two groups. Results After use of propess, the cervical Bishop score of the study group was score ≥2 in 24 cases,while 5 cases whose score ≥2 in control group （ P 〈0.05） ; The time from administration to mobilizi （27.70±7.10）h （ P 〈0. ng 05 the control group was （11.8 labor was （11.50±7.31）h in the study group,the control group was the contral group was 57% （ P 〈0.05） ; There was no significant difference between the two groups in fetal distress rate and neonatal asphyxia rate （P 〉 0.05）. Conclusion There were satisfactory results about clinical evaluations of propess for cervical ripening in prolonged pregnancy.

关 键 词：妊娠 过期 宫颈成熟 引产 

分 类 号：R714.21[医药卫生—妇产科学]