肿瘤坏死因子α、白介素6及白介素8在小儿支气管肺炎中检测的临床意义  

Clinical significance of changes of serum tumor necrosis factor-α, interleukin-6 and interleukin-8 levels in children with bronchopneumonia

作　　者：张建梅[1] 陈欣[1] 任静[1] 郝锦丽[1] 张亚京[1] 

机构地区：[1]内蒙古医学院第三附属医院儿科,包头014010

出　　处：《国际呼吸杂志》2008年第14期833-834,共2页International Journal of Respiration

摘　　要：目的探讨血清肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）、白介素6（interleukin-6，IL-6）和IL-8的水平与小儿肺炎的关系。方法采用放射免疫法对60例支气管肺炎患儿（分为轻型和重型）进行了TNF-α、IL-6和IL-8水平检测，并与30名正常健康儿童作比较。结果重型肺炎与轻型肺炎患儿血清TNF-α、IL-6和IL-8水平均高于正常对照组（P值均〈0．01），重型肺炎患儿血清TNF-α、IL-6和IL-8水平均高于轻型肺炎患儿（P值均〈0．01）。肺炎患儿血清TNF-α、IL-6和IL-8之间呈显著正相关（P值均〈0．001）。结论TNF-α、IL-6和IL-8在小儿肺炎中起重要作用，检测支气管肺炎患儿血清TNF-α、IL-6和IL-8的水平对诊断、治疗和预后均有一定的临床意义。Objective To investigate the association of serum tumor necrosis factor-α （TNF-α）, interleukin-6（IL-6） and IL-8 levels in children with bronchopneumonia. Methods Serum TNF-α,IL-6 and IL-8 contents were measured by radioimmunity method in 60 children with bronchopneumonia （mild and severe） and 30 controls. Results Serum levels of TNF-α, IL-6 and IL-8 in children with mild and severe bronchopneumonia were significantly higher than those in controls（all P 〈0.01）. Serum levels of TNF-α, IL-6 and IL-8 were significantly higher in children with severe bronchopneumonia than those in children with mild bronchopeumonia（all P 〈0.01）. Serum levels of TNF-α, IL-6 and IL-8 were positively correlated with each other in children with bronchopneumonia （all P 〈 0. 001）. Conclusions TNF-α, IL-6 and IL-8 have important roles in children with bronchopneumonia. Determination of serum TNF-α, IL-6 and IL-8 levels might have important prognostic values in children with bronchopneumonia.

关 键 词：支气管肺炎 肿瘤坏死因子Α 白介素6 白介素8 

分 类 号：R72[医药卫生—儿科]