正负性情绪图片编码加工功能磁共振成像研究  

Functional MRI Study of Encoding Processes of Positive and Negative Emotional Pictures

作　　者：王海宝[1] 谌业荣[1] 余永强[1] 张诚[1] 张达人[2] 

机构地区：[1]安徽医科大学第一附属医院放射科,230022 [2]中国科学技术大学合肥微尺度物质科学国家重点实验室和生命科学院认知神经心理学实验室,230026

出　　处：《临床放射学杂志》2008年第7期869-873,共5页Journal of Clinical Radiology

基　　金：安徽省自然科学基金资助项目(No:50430601)

摘　　要：目的探讨正负性情绪图片加工所涉及的相关神经机制。资料与方法对20名健康自愿者（男女各10名,年龄20~25岁,视觉呈现彩色负性、正性、中性情景图片）行功能磁共振成像扫描并进行后处理。结果与中性图片加工相比,正负情绪激活杏仁核、前额叶不同亚区、扣带回、颞中回、颞上回等共同脑区。负性图片显著激活双侧杏仁核、右侧前额叶眶回、左侧海马、丘脑和梭状回等脑区;正性图片激活右侧杏仁核、左侧前额叶背侧和右侧海马等脑区。结论正负性情绪加工涉及共同的和相对特异的神经机制。前额叶和杏仁核等是情绪加工中的重要结构,前额叶参与情绪加工符合情绪效价假设。Objective To explore the corresponding neural mechanisms involved in the process of the positive and the negative emotional pictures. Materials and Methods 20 normal subjects participated in the study, viewing the color episodic pictures including positive, negative and neutral pictures while functional MRI scans were performed and postprocessing of the functional data was completed. Results Compared with the neutral pictures,the emotional picture processes in- volved various brain regions including the amygdala,prefrontal cortex,middle and superior temporal gyrus and anterior cingulate gyms, etc.. The negative pictures activated the brain regions including the bilateral amygdala, right orbital gyrus,left hippocampus, thalamus and fusiform gyms, etc. , while the positive evoked the right amygdala, left dorsal prefrontal cortex and right hippocampus,etc. Conclusion The positive and negative emotional encoding processes involved in common and relatively specific neural mechanisms. Amygdala and various prefrontal subcortex were the important structures in the differ- ent emotional picture processes. Participation of prefrontal lobe in emotional processing was consistent with emotional valence hypothesis.

关 键 词：情绪 编码 杏仁核 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R395.6[医药卫生—诊断学]