植物泛素/26S蛋白酶体途径研究进展  

The Progress on The Ubiquitin 26S Proteasome Pathway in Plants

作　　者：黄海杰[1] 陈雄庭[1] 

机构地区：[1]中国热带农业科学院生物技术研究所,海口571101

出　　处：《中国生物工程杂志》2008年第7期127-132,共6页China Biotechnology

基　　金：热带作物种质资源平台项目专题经费资助项目(2005DKA21000-5-62)

摘　　要：泛素/26S蛋白酶体途径是最重要的、有高度选择性的蛋白质降解途径,由泛素激活酶、泛素结合酶、泛素蛋白连接酶和26S蛋白酶体组成,参与调控植物生长发育的多个方面。泛素蛋白酶体途径参与植物体内的众多生理过程,如植物激素信号、光形态建成、自交不亲和反应和细胞周期等。就泛素/26S蛋白酶体途径以及在植物生长发育中的作用的研究近况做一综述。Selective protein degradation by the ubiquitin 26S proteasome pathway has emerged as a key regulatory mechanism in a wide variety of cellular processes. The ubiquitin/26S proteosome pathway mainly consists of ubiquitin activating enzyme （ E1 ）, ubiquitin conjugating enzyme （ E2 ）, ubiquitin protein ligase （ E3 ）, and 26S proteasome. In an ATP-dependent reaction,uibquitin （Ub） is conjugated to E1 ,the activated Ub is then transferred to an E2. Finally, the Ub-E2 intermediate delivers the Ub to the target protein by E3 recognition. Polyubiquinated proteins are eventually degraded by the 26S proteasome. In plants, regulated protein degradation by/26S proteasome pathway contributes significantly to development by affecting a wide range of progress, including hormone signaling, photomorphogenesis, self- incompatibility and cell cycle. The recent progress towards understanding the role of the Ub/26S proteasome pathway during plant development was reviewed.

关 键 词：泛素 26S蛋白酶体 植物激素 光形态建成 自交不亲和反应 细胞周期 

分 类 号：Q51[生物学—生物化学]