无机纳米粒子作为基因载体的研究进展  

Progress of inorganic nanoparticles as gene delivery vectors

作　　者：李新新[1] 侯森[1] 冯喜增[1] 

机构地区：[1]南开大学生命科学学院,生物活性材料教育部重点实验室,天津300071

出　　处：《生命科学》2008年第3期402-407,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金重大项目(90403140)

摘　　要：转染是将具生物功能的核酸转移、运送到细胞内,并使其在细胞内维持生物功能的过程。作为现代生物化学和分子生物学中的一种主要技术手段,转染对于基因治疗有重要的意义。无机纳米粒子作为基因载体受到人们日益广泛的关注,其具有易于制备,可进行多样化的表面修饰等多种优势。本文将概述无机纳米粒子作为基因载体的现状及其对基因表达的影响。Transfection is defined as the delivery of functional nucleic acids into living cells, maintaining the biological function of the nucleic acids. As an important technique in biochemistry and molecular biology, transfection is meani.ngful for its potential applications in gene therapy. Inorganic nanoparticles can be used as gene delivery vectors and have received extensive interest due to their various advantages, such as easy preparation and surface-functionalization. This paper reviewed the current researches about inorganic nanoparticles as gene delivery vectors. Their influence on the gene expression was also discussed.

关 键 词：转染 无机纳米粒子 基因载体 基因治疗 

分 类 号：TN383[电子电信—物理电子学] Q782[生物学—分子生物学]