阴道用替硝唑缓释微囊的制备及其体外释放度考察  

Preparation of vaginal tinidazole microcapsules and observation of its release rate in vitro

作　　者：徐丹[1] 朱照静[1] 程安媛[1] 

机构地区：[1]重庆医科大学药学院,重庆400016

出　　处：《中国医院药学杂志》2008年第12期994-996,1017,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备替硝唑缓释微囊,考察其在体外的释放度。方法:以明胶、阿拉伯胶为囊材,采用复凝聚法制备替硝唑缓释微囊,正交试验优化制备工艺,采用紫外分光光度法测定含量。以100mLpH4.5的乳酸溶液为释放介质,温度(37±0.5)℃,转速50r·min-1测定其体外释放度。结果:替硝唑缓释微囊的最佳制备工艺为囊心囊材质量比为1∶1,温度50℃,甲醛用量为2mL·(120mL)-1(甲醛用量/系统体积),体外缓释时间为240min。结论:替硝唑缓释微囊的制备工艺简单、成囊性和重复性好,替硝唑微囊具有明显的缓释效果。OBJECTIVE To prepare tinidazole microcapsules and study its release rate in vitro. METHODS Tinidazole microcapsules were prepared by complex coacervation and orthogonal design. Tinidazole content was determined by spectrophotometry. 100 mL lactic aid solution was used as the releasing media, the temperature was（37±0. 5）℃ and the rate of rotation was 50 r·min^-1, This methord was used to diterminate its release rate in vitro. RESULTS The optimized conditions were： the ratio ot tinidazole and coating material ot 1 ： 1, temperature ot 50℃ ,and a hardening agent ot 2 mL per 120 mL ot coacervation system. The microcapsules could be released for 240 min in vitro. CONCLUSION The reparation methord is simple, reproducible, and the microcapsules have good appearance. Tinidazole microcapsules have obvious sustained-release effect compared with bulk drug.

关 键 词：替硝唑 明胶-阿拉伯胶 微囊 复凝聚法 体外释放度 

分 类 号：R943[医药卫生—药剂学]