骨髓造血干细胞微环境  

Bone Marrow Hematopoietic Stem Cell Niches

作　　者：唐红梅[1] 马静[1] 韩代书[1] 

机构地区：[1]中国医学科学院基础医学研究所,北京协和医学院基础医学院细胞生物学系,北京100005

出　　处：《细胞生物学杂志》2008年第3期323-328,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30570678)~~

摘　　要：近来成体干细胞的研究进展为许多重大疾病的治疗带来了新的希望。造血干细胞(hematopoietic stem cells,HSCs)是迄今认识到的最为典型的成体干细胞,骨髓是干细胞研究的主要组织,许多成体干细胞的概念及其基本特征源于对骨髓中造血干细胞的研究。近年来的重要进展之一是微环境对HSCs的调节功能,干细胞微环境有准确的解剖学定位,也是一个生理功能的基本单位,整合介导机体对干细胞需求的反应信号,从而调节干细胞的数量和命运。在病理条件下,微环境仍然调节干细胞的功能,因此对造血微环境的认识已成为干细胞研究的中心内容。现对骨髓造血干细胞微环境的组成、信号及修饰的研究进展进行综述,为深入研究干细胞微环境的结构和功能提供背景资料。Recent studies on the adult stem cells provide novel insight into treatment of many diseases. The hematopoietic stem cells （HSCs） are the best characterized adult stem cells. Bone marrow is the major tissue where HSCs reside and that is focused on stem cells research. Many concepts and characteristic of adult stem cells were achieved based on investigation of HSCs in bone marrow. Recently, studies on the role of niche in regulating development of HSCs have progressed rapidly. Stem cell niche, which is basic physiological unit, has been anatomi- cally located. The niche mediates and integrates many signals that control the numbers and fate of HSCs in basal state. Furthermore, hematopoietic niche also function under the pathological conditions. Therefore, the studies in this area mainly focus on the hematopoietic niches. Here, we tried to review the progress in the components, signals and modification of hematopoietic niches in order to provide references for the study on stem cell niche.

关 键 词：造血干细胞 微环境 信号通路 

分 类 号：Q2[生物学—细胞生物学]