Mechanisms of p53-mediated mitochondrial membrane permeabilization  

作　　者：Eugenia Morselli 

机构地区：[1]INSERM, U848, 39 rue Camille Desmoulins, 94805 Villejuif, France [2]Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France [3]Universite Paris-Sud XI, 39 rue Camille Desmoulins, 94805 Villejuif, France

出　　处：《Cell Research》2008年第7期708-710,共3页细胞研究（英文版）

摘　　要：The p53 protein is mutated or inactivated in more than 50% of human cancers, underscoring its cardinal importance as an oncosuppressor, p53 is expressed in all nucleated cells and can be activated by a plethora of post-transcriptional modifications （in particular by the phosphorylation of critical serine residues）, as well as by the inhibition of its degradation （mainly mediated by the E3 ubiquitin ligase MDM2）. p53 was first characterized as a transcription factor that, once activated, drives the expression of gene programs causing a transient cell cycle arrest linked to DNA repair, a permanent and irreversible cell cycle arrest （senescence） or programmed cell death by apoptosis.

关 键 词：DNA 细胞循环 基因表达 细胞衰亡 

分 类 号：Q78[生物学—分子生物学] Q25