超抗原及其增强疫苗免疫效应的意义  

Superantigens and its effect on the immune responses induced by vaccine

作　　者：郜世隽[1] 林晨[1] 

机构地区：[1]暨南大学医学院微生物和免疫教研室,广州510632

出　　处：《癌症进展》2008年第4期352-356,共5页Oncology Progress

基　　金：广东省自然科学基金(06025169);广东省科技计划项目(2005B50301016);广州市科技攻关计划(2003J1-I0011;2005Z1-E4015);中德生物技术合作项目(CHN02/319);血液病学国务院侨办重点学科建设基金;暨南大学病理开放实验室基金

摘　　要：超抗原(superantigen,SAg)是一类具有多种免疫活性的特殊抗原分子,主要是一些细菌毒素和逆转录病毒基因产物。超抗原不受MHC限制,选择性地识别T细胞的抗原受体TCRVβ链,对CD4^+T细胞和CD8^+T细胞都具有强大的活化作用。超抗原概念一经提出,其在治疗恶性肿瘤上的潜力便受到重视。本文综述超抗原生物学特性,与T细胞受体的关系以及超抗原在增强疫苗刺激免疫应答中所取得的进展。Superantigens （SAGs） are specific antigen molecules with multiple immunologic activities, which mainly include microbial toxins and endogenous retroviral gene products. Superantigens can strongly stimulate the activation of T cells bearing particular TCR Vβ regions without restriction of MHC. Both CD4^＋ and CD8^＋ T cells can be fully activated by SAGs, which provides an attractive way to explore the potential anti - tumor mechanisms of SAGs. In this article, we reviewed the biological characteristics of SAGs, the relationship between TCR and SAGs, and especially the effects of SAGs on immune responses induced by certain vaccines.

关 键 词：超抗原 疫苗 T细胞 

分 类 号：R392.11[医药卫生—免疫学]