余甘子叶提取物对慢性支气管炎并肺气肿大鼠的保护作用研究  

Protective Effects of the Extracts from Leaves of Phyllanthus emblica L.on Chronic Bronchitis and Emphysema in Rats

作　　者：钟振国[1] 曾春兰[2] 

机构地区：[1]广西中医学院新药研究开发中心,广西南宁530001 [2]广西工业职业技术学院,广西南宁530001

出　　处：《时珍国医国药》2008年第4期863-866,共4页Lishizhen Medicine and Materia Medica Research

基　　金：广西科学技术厅资助项目(No.0639051,0718002-2-1);广西高校人才小高地建设创新团队资助计划

摘　　要：目的研究余甘子叶提取物是否对慢性支气管炎并肺气肿大鼠有保护作用。方法采用气管内注入脂多糖(LPS)及烟熏的混合刺激方法建立慢性支气管炎并肺气肿大鼠模型,采用病理组织切片及血气分析方法观察余甘子叶提取物对慢性支气管炎及肺气肿的病理及血氧含量的影响。结果余甘子叶提取物乙酸乙酯膏(cc)部位对由LPS+烟熏引起的慢性支气管炎并肺气肿大鼠的支气管炎症及肺泡病理损害有明显保护作用,能减少支气管壁炎症细胞浸润及肺大泡形成,并能提高动脉血氧含量,各项指标均优于模型对照组及阳性药物组,而接近于正常对照组。结论余甘子叶提取物cc部位具有防治慢性支气管炎并肺气肿的作用。Objective To study the effect of the extract from leaves of PhyUanthus emblica L. on chronic bronchitis and emphysema in rats, and provide experimental basis for the exploitation of the leaves of PhyUanthus emblica L. Methods The rat model of chronic bronchitis and emphysema was established by intratracheal instillation of lipopolysaccharide （LPS） twice and exposed to cigarette smoke daily. Results The cc part could obviously lessen the infictration of inflammatory cells and formation of emphyse- ma, increase arterial oxygen content, most of observational indexes were better than those in model group and EM treated group. Conclusion The cc part has obviously protective effet on chronic bronchitis and emphysema.

关 键 词：余甘子叶提取物 慢性支气管炎 肺气肿 

分 类 号：R285.5[医药卫生—中药学]