人参须超微粉醇提液对去卵巢大鼠血脂的影响  

Regulatory Effects of the Alcohol Extracts of Ginseng Fibrous Root on the Blood Lipid of Ovariectomized Rats

作　　者：张益嘉[1] 吴铁[1] 吴怡[2] 崔燎[1] 张新乐[1] 吴光樑[1] 周湘君[1] 李彬[1] 

机构地区：[1]广东医学院,广东湛江524023 [2]广东医学院医药科技开发中心,广东湛江524023

出　　处：《时珍国医国药》2008年第4期877-879,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省科技计划项目(No.2005B10401037)

摘　　要：目的观察人参须超微粉醇提液对去卵巢大鼠血脂水平的调节作用。方法32只SD雌性大鼠随机分为4组,每组8只,以去卵巢大鼠为血脂紊乱模型,预防用药90 d,观察人参须超微粉醇提液中、低剂量等分别对大鼠血脂谱各值以及体重、肝脏、子宫重量等的影响。结果与假手术组比,去卵巢组大鼠体重、总胆固醇(TC)明显升高(P<0.01或P<0.05),甘油三酯(TG)升高不明显,高密度脂蛋白胆固醇(HDL-c)和子宫重量显著下降(P<0.01或P<0.05);与去卵巢组相比,人参须超微粉醇提液中、低剂量可显著降低TC水平、升高HDL-c水平(P<0.05或P<0.01),对体重、子宫重量没有显著影响,中剂量人参醇提液还能降低TG(P<0.05)与升高HDL-c/TC值(P<0.01)。结论去卵巢能造成大鼠血脂紊乱,中药人参须的超微粉醇提液能有效改善其血脂水平。Objective To study the regulatory effects of the alcohol extracts of Ginseng fibrous root on the blood lipid of ovafiectomized rats. Methods 32 female Sprague - Dawley rats were randomly divided into sham operation group （sham） ,ovariectomized group （OVX） and two different dosages of the alcohol extracts of ginseng fibrous root treated groups （ GSL＆GSM ）. The levels of serum lipid and body weights, liver and uterus weight were measured after 90 days treatment. Results Ovariectomized rats had much higher total cholesterol （ TC ） （ P 〈 0.05 ） and body weight （ P 〈 0, 01 ） as compared to Sham group. A significant decrease in high density lipoprotein cholesterol （ HDL - C ） （ P 〈 0.01 ） and uterus weight （ P 〈 0. 05 ） were also observed though no significant elevation in triglyeride （TG） was reported, GSL and GSM lowered serum TC（P 〈0. 01 ） and enhanced HDL - C（P 〈0. 05 or P 〈 0.01 ）, and had no effect on body weight or uterus weight, GSM also enhanced HDL/TC value （P 〈 0. 01 ） and lowered TG（P 〈 0. 05 ） as well, Conclusion The alcohol extracts of Ginseng fibrous root can regulate the blood lipid in ovarieetomized rats.

关 键 词：人参须 去卵巢大鼠 血脂类 

分 类 号：R285.5[医药卫生—中药学]