注射用炎琥宁与甲硝唑注射液的配伍稳定性考察  

Study on the Stability of the Mixture of Injection Natrii Kalii Dehydroandrographolidie Succinate and Metronidazole Injection

作　　者：时晓亚[1] 陈富超[1] 于琳[1] 方宝霞[1] 陈学珍[2] 樊烽[2] 

机构地区：[1]郧阳医学院附属东风总医院,湖北十堰442008 [2]郧阳医学院药检学院2003级实习生,湖北十堰442000

出　　处：《时珍国医国药》2008年第4期992-993,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的考察注射用炎琥宁与甲硝唑注射液的配伍稳定性。方法在室温(25℃)下,采用紫外分光光度法测定注射用炎琥宁与甲硝唑注射液的含量,8 h内各时间段考察配伍液的含量、外观性状、紫外光谱、pH值及微粒数变化。结果配伍液外观、pH值及含量均无明显变化。结论注射用炎琥宁与甲硝唑注射液配伍后在室温下8 h内可使用。Objective To study the stability of the mixture of Injection Natrii Kalii Dehydroandrographolidie Succinate and Metronidazole injection. Methods The contents were determined by UV spectrophotometry after mixing of Injection Natrii Kalii Dehydroandrographo -lidie Succinate with Metronidazole injection under the room temperature within 8 hours, and the appearance, pH values, UV spectrum, numbers of particles of the solution were observed. Results No significant differences were found in terms of the appearance ,pH value and the contents of the mixed solution. Conclusion The mixture of Injection Natrii Kalii Dehydroandrographolidie Succinate with Metronidazole injection can be used under room temperature within 8 hours of mixing.

关 键 词：炎琥宁 甲硝唑 配伍 稳定性 

分 类 号：R284.1[医药卫生—中药学]