竹节人参总皂苷抗炎作用的实验研究  

Study on the Anti-inflammatory Effects of Total Panax japonicus Saponins

作　　者：文德鉴[1] 陈国栋[1] 张翠兰[2] 董兴高[1] 肖本见[1] 

机构地区：[1]湖北民族学院医学院,湖北恩施445000 [2]湖北民族学院附属医院,湖北恩施445000

出　　处：《时珍国医国药》2008年第5期1155-1156,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察竹节人参总皂苷的抗炎作用,以确定竹节人参抗炎作用的活性部位。方法通过二甲苯致小鼠耳廓肿胀实验及醋酸致小鼠腹腔毛细血管通透性实验,观察竹节人参总皂苷对炎症的影响。结果竹节人参总皂苷高、低剂量组对二甲苯所致小鼠耳廓肿胀的抑制作用,与生理盐水组比较有显著性差异(P<0.01),对醋酸致小鼠腹腔毛细血管通透性的抑制作用与生理盐水组比较也具有显著性差异(P<0.05,P<0.01)。结论竹节人参总皂苷具有明显的抗炎作用,是竹节人参发挥抗炎作用的主要活性部位。Objective To study anti - inflammatory effects of total Panax japonicus saponins （ tPJS ）. Methods Ear edema induced by dimethylbenzene and abdominal capillary permeability induced by acetic acid in mice were used to study the anti - inflammatory effects. Results tPJS （ 1 g/kg and 2g / kg） could inhibit ear edema（ P 〈0.01 ） and reduce the abdominal capillary permeability（P 〈 0.05 ,P 〈 0.01 ）. Conclusion tPJS has anti -inflammatory effects, and it is the main active part of Panax japonicus on anti - inflammatory effects,

关 键 词：竹节人参总皂苷 活性部位 抗炎作用 药理作用 

分 类 号：R285.5[医药卫生—中药学]