葛根素对心肌缺血-再灌注损伤的保护机制及其临床应用  

The Protective Mechanism and Clinical Application of Puerarin on the Myocardial Ischemia-Reperfusion Injury

作　　者：周玉娟[1] 魏继承[1] 

机构地区：[1]泸州医学院附属医院,四川泸州646000

出　　处：《时珍国医国药》2008年第5期1259-1260,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：葛根素系从中药葛根中提取出来的中药单体成分,对缺血再灌注(IR)损伤的心肌细胞凋亡具有抑制作用,作用点在再灌注期,可促进再灌流时心脏功能的恢复,并能改善缺血再灌注后的心肌超微结构(特别是线粒体)。Puerarin is monomer component extracted from a traditional Chinese herb called pueraria, The results of up - to - date laboratory and clinical studies demonstrated that Puerarin may attenuate ischemia - reperfusion injury and promote recovery of myocardial function by mechanisms such as inhibiting myocardial apoptosis, increasing SOD activity, downregulating Bax expression, upregulating Bcl - 2, inhibiting production of pro - inflammatory cytokines, and improving the myocardial ultramicrostucture, etc,

关 键 词：葛根素 心肌缺血再灌注损伤 保护机制 临床应用 

分 类 号：R962[医药卫生—药理学]