复方中药对黑素细胞迁移和黏附的影响  

Effects of a Chinese medicine compound on melanocyte adhesion and migration

作　　者：牟宽厚[1] 张宪旗[2] 冯捷[3] 

机构地区：[1]西安交通大学第一临床医学院皮肤科,西安710061 [2]浙江大学医学院第一临床医学院皮肤科,杭州310027 [3]西安交通大学第二临床医学院皮肤科,西安710004

出　　处：《中国麻风皮肤病杂志》2008年第7期532-534,共3页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(30200247)

摘　　要：目的:确定复方中药乙醇提取物对体外培养黑素细胞黏附、迁移的影响。方法:复方中药用70%乙醇提取,正常人黑素细胞来自包皮环切术切取的包皮组织。用包被纤维黏连蛋白的培养板检测黑素细胞黏附,用微孔膜研究黑素细胞迁移。结果:复方中药1号和3号乙醇提取物可促进黑素细胞黏附和迁移(P<0.05),而1、2和3号可以促进黑素细胞迁移(P<0.05)。结论:部分复方中药可能通过促进黑素细胞黏附和迁移途径对白癜风起治疗作用。Objective： To determine the effect of ethanol extract from a Chinese medicine compound on melano- cyte adhesion and migration in vitro. Methods： Extract was obtained from the a Chinese medicine compound with 70% of ethanol. Human melanocytes were from neonatal foreskins. Melanocyte adhesion assay was tested with covered fibroneefin. The migration of melnocytes was assessed using micropore filter method. Results： The extracts of the compound 1, 2 and 3 increased human melanocyte migration on fibronectin and the compound 1 and 3 promoted human melanecyte adhesion. Conclusion： The mechanism of some traditional Chinese medicines in the treatment of vitiligo may be by stimulating migration and/or adhesion of melanocytes.

关 键 词：黑素细胞 白癜风 中药 乙醇 

分 类 号：R285[医药卫生—中药学]