米非司酮对人早孕绒毛及蜕膜中骨桥蛋白和绒毛膜促性腺激素-β表达的影响  

The Influence of Mifepristone on the Expression of OPN and β-hCG in the Chorion and Decidua of Early Pregnancy

作　　者：李迎军[1] 王蔼明[1] 张雷[2] 商微[1] 冯利霞 

机构地区：[1]海军总医院妇产科,北京100037 [2]河北医科大学组胚教研室,石家庄050017 [3]邢台县三院妇产科,邢台054000

出　　处：《生殖与避孕》2008年第7期436-440,共5页Reproduction and Contraception

摘　　要：目的:探讨米非司酮对早孕绒毛及蜕膜中骨桥蛋白(OPN)和绒毛膜促性腺激素-β(β-hCG)表达的影响。方法:采用免疫组化半定量法检测米非司酮药物流产(n=20)和人工流产(n=20)的早孕绒毛及蜕膜中的OPN(骨桥蛋白)和β-hCG的表达。结果:OPN和β-hCG在早孕妇女绒毛组织和蜕膜组织中的表达米非司酮组均显著低于手术流产组,差异有统计学意义(P<0.01)。结论:米非司酮可能抑制了早孕绒毛及蜕膜中OPN和β-hCG的合成,进而影响胚泡着床和胎盘的形成,使妊娠难以维持,最终流产。Objective：To explore the influence ofmifepristone on the expression of OPN and β-hCG in the chorion and decidua of early pregnancy. Methods： The patients with the 40 days＇ pregnancy, who suppressed menstruation 35-49 days and did not want to pregnancy come forward demended termination of pregnancy, they were divided into mifepristone grop and artificial abortion by surgical aspiration grop.every grop has 20 days＇ pregnancy, we used the immunohistochemistry semiquantitative method to detect the expression of OPN and β- hCG in the chorion and decidua of early pregnancy. Results： （1） The effect of mifepristone on the immunohistochemical reaction intensity of OPN in the chorion and decidua from the early pregnancy mifepristone grop was significant lower than artificial abortion by surgical aspiration grop. difference has statistical significance （P〈0.01） （2） The effect of mifepristone on the immunohistochemical reaction intensity of β-hCG in the chorion and decidua from the early pregnancy mifepr/stone grop was significant lower than artificial abortion by surgical aspiration grop. difference has statistical significance （P〈0.01）. Conclusion： OPN and β-hCG were related to embryo nidation, as well as to keep normal early pregnancy. The mifepristone was able to inhibit the synthesis of the OPN and β-hCG during the early pregnant stage as well as the capability of the adhesion,the proliferation and the migration of the trophocyte and the decidual cells.So both the imbedding of the blastocyst and the placental formation are affected, the corepus luteum was decreased, it＇s hard for the patients to have a fetation,then the abortion occursed.

关 键 词：米非司酮 骨桥蛋白(OPN) 绒毛膜促性腺激素-β(β-hCG) 蜕膜 绒毛 免疫组织化学 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]