原发性肝癌超声造影彩色血管密度与病理微血管密度的对比分析  

Mean color vessel density with contrast-enhanced ultrasound and microvessel density： comparative study

作　　者：赵玉珍[1] 周军华[2] 董超[2] 刘红磊[2] 祝晓东[1] 赵小华[1] 王瑛[1] 

机构地区：[1]卫生部中日友好医院超声科,北京100029 [2]河北医科大学第四医院超声科

出　　处：《中华超声影像学杂志》2008年第7期581-583,共3页Chinese Journal of Ultrasonography

基　　金：河北省科技厅重点攻关项目（05276101 D-69）

摘　　要：目的探讨原发性肝癌（HCC）术前超声造影（CEUS）定量、半定量血流灌注参数与术后病理微血管密度（MVD）的相关性。方法HCC34例术前行CEUS，超声造影能量多普勒（CEUS-PD）状态下选取血流信号最丰富的切面，计算机计测病灶平均彩色血管密度（MCVD），并对图像血流信号进行半定量分级，所得定量、半定量参数与术后病理组织免疫组化染色计测的MVD对照，进行相关性分析。结果CEUS-PD状态下34例病灶血流信号最丰富切面MCVD为0．17±0．09，术后病理组织切片免疫组化染色计测的MVD为（62．59±23．96）／400倍视野，二者呈正相关（r=0．56，P〈0．05）；病灶血流信号分级为：Ⅰ级3例，Ⅱ级12例，Ⅲ级19例；血流信号各半定量分级的MVD存在差异（F=8．06，P〈0．05），趋势检验表明各半定量分级的MVD无线性趋势（F=7．57，P〉0．05）。结论HCC术前CEUS-PD状态下计测的MCVD与术后病理MVD呈正相关，可于术前评价肿瘤的血流灌注。Objective To investigate the correlation, between quantitative parameters with contrastenhanced ultrasound-power Doppler （CEUS-PD） and microvessel density （MVD） in hepatocellular carcinoma （HCC）. Methods Thirty-four cases with HCC underwent CEUS before operation. The satisfactory images were selected through CEUS-PD and analyzed with computer to calculate mean color vessel density（MCVD）. The blood flows of focal lesions were graded into 0- Ⅲ based on the numbers of color vessels with CEUS-PD. The correlation between those parameters and MVD counted with immunohistochemistry was analyzed after operation. Results In 34 cases with HCC,the MCVD of focal lesions with CEUS-PD was 0.17 ± 0.09,the pathologic MVD was （62.59 ± 23.96）/400 x after operation. The MCVD was positively correlated to MVD（ r = 0.56, P （0. 05）. In 34 cases HCC,3 cases were in grade I , 12 cases were in grade Ⅱ , 19 cases were in grade Ⅲ. There was significant differences in pathologic MVD of every grade （ F = 8.06, P 〈0.05）. But there was no linear tendency in the grades（ F = 7.57, P 〈0.05）. Conclusions In focal lesions of 34 HCC, MCVD calculated with CEUS-PD was positively correlated to pathologic MVD. It can be used to evaluate tumor blood perfusion exactly before operation.

关 键 词：超声检查 微气泡 癌 肝细胞 新生血管化 病理性 

分 类 号：R686[医药卫生—骨科学]