刺激家兔隔核对海马痛单位电活动的影响  

EFFECT OF STIMULATING SEPTAL NUCLEUS ON PAIN NEURONS OF HIPPOCAMPUS

作　　者：覃筱燕[1] 黄忠致[1] 刘荫仁[1] 

机构地区：[1]广西医科大学生理学教研室

出　　处：《广西医科大学学报》1997年第4期55-57,共3页Journal of Guangxi Medical University

摘　　要：在三碘季胺酚制动下，对３９只清醒麻痹的家兔进行实验，探讨隔核对海马痛单位的作用及其可能机制。结果发现，海马的痛单位占引导总数的２８．３７％，其中以痛兴奋单位为主（占痛单位的７０．３４％）。海马有８０．５１％的痛单位对刺激隔核起反应，含痛兴奋性神经元（ＰＥＮ）７１个，痛抑制性神经元（ＰＩＮ）２４个。其中受隔核影响出现减频反应的海马痛单位有７２个，占７５．７９％，含ＰＥＮ６１个，ＰＩＮ１１个；受隔核影响出现增频反应的海马痛单位有２３个，占２４．２１％，含ＰＥＮ１０个，ＰＩＮ１３个。脑室注射阿托品或氟哌啶醇均可阻断刺激隔核对海马的影响效应。提示：隔核参与对海马痛单位的调制；刺激隔核对海马痛单位以抑制性调制为主，并主要作用于ＰＥＮ；乙酰胆碱、多巴胺及相应的受体可能参与其调制。Microelectrode recording method was used to investigate the effect of stimulating septal nucleus (SN) on pain neurons of hippocampus (HPC) in conscious but movement inhibited rabbitsResults:The pain units of HPC amounted to 2827% of the total number of the recorded neurons8051% of these pain units responded to SN stimulation,of which 72 were pain excitory neurons (PEN) and 24 were pain inhibitory neurons(PIN)When SN was stimulated,the electric discharge frequency of 72 HPC pain units(61 PEN and 11 PIN) was decreased (7579%)On the other hand,the electric discharge frequency of 23 HPC pain units (10 PEN and 13 PIN) was increased (2421%)Intracerebroventricular injection of atropine or haloperidol blocked the response of the pain units to SN stimulationThe results suggest that SN takes part in the modulation of the pain units of HPCStimulation of SN produces mainly inhibitory modulation effect on HPC pain units,and affects mainly the pain excitory neuronsAcetylcholine,dopamine and their receptors might be involved in such modulating mechanism

关 键 词：隔核 海马 玻璃微电极 痛单位 电刺激 

分 类 号：R338.26[医药卫生—人体生理学]