膜结合型前列腺素合酶-1在鼻息肉中的检测  

Detection of microsomal-type Prostaglandin E synthase-1 in nasal polyps

作　　者：张月琴[1] 于小玲[1] 尚芳芳[1] 齐瑞芳[1] 

机构地区：[1]青岛大学医学院病理生理学教研室,山东青岛266021

出　　处：《中国现代医学杂志》2008年第13期1902-1904,共3页China Journal of Modern Medicine

摘　　要：目的探讨前列腺素E2生成的终末酶——膜结合型前列腺素合酶(mPGEs-1)在鼻息肉组织中的表达及意义。方法采用免疫组织化学SP法对34例鼻息肉和10例正常下鼻甲黏膜中mPGEs-1的蛋白表达进行检测。结果mPGEs-1在正常下鼻甲黏膜组织中无或少量表达,在鼻息肉组织中显示高表达;Ⅲ型鼻息肉组织中mPGEs-1的阳性表达面积和密度均高于Ⅱ型鼻息肉组(P<0.05)。结论mPGEs-1在鼻息肉组织中高表达,而且与鼻息肉的分型有关;mPGEs-1的高表达可能是鼻息肉发生、发展的重要因素。[Objective] To detect the expression and clinical significance of microsomal-type Prostaglandin E synthase-1 （mPGEs-1） in nasal polyps. [Methods] Immunohistochemistry was used to detect the expression of mPGES-1 in 34 cases of nasal polyps and 10 cases of normal mucosa. [Results] The protein expression of mPGEs- 1 is negatively or lowly expressed in normal mucosa. All sections of nasal polyps showed significantly overexpression of mPGEs-1. The positive area and density of mPGEs-1 in type Ⅲ are higher than that in type Ⅱ（P〈0.05）. [Conclusion] The mPGEs-1 is over-expressed in nasal polyps, and the upregulated mPGEs-1 correlates with classification of nasal polyps. Over expression of mPGEs-1 may be an important factor in the development and progression of nasal polyps.

关 键 词：鼻息肉 分型 MPGES-1 免疫组织化学 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]