冠心病患者血清VEGF和血小板水平变化及意义  

Changes of serum VEGF and platelet levels in patients with coronary heart disease and its clinical significance

作　　者：齐法莲[1] 徐军[1] 李晓燕[2] 陈英剑[1] 孙黎[1] 

机构地区：[1]济南军区总医院实验诊断科,山东济南250031 [2]济南军区总医院心内科,山东济南250031

出　　处：《中国现代医学杂志》2008年第13期1935-1936,1939,共3页China Journal of Modern Medicine

摘　　要：目的探讨冠心病患者血清血管内皮生长因子(VEGF)和血小板水平变化及临床意义。方法123例冠心病患者分为4组:心绞痛(AP)组39例,急性心肌梗死(AMI)组32例,陈旧性心梗(OMI)组22例,对照组30例,血清VEGF采用酶联免疫吸附实验(ELISA)检测。结果AP组、AMI组和OIM组VEGF水平明显高于对照组(P<0.01),AMI组明显高于AP组(P<0.05),但与OMI组比较则差异无显著性(P>0.05);AMI组与对照组、AP组和OMI组比较血小板水平均明显升高(P<0.01,P<0.01,P<0.05)。结论血清VEGF和血小板测定对于冠心病,特别是AMI患者的病情观察具有一定临床意义。[Objective] To investigate changes of serum Vascular Endothelial Growth Factor （VEG10 and platelet levels in patients with coronary heart disease and its clinical significance. [Methods] 123 patients with coronary heart disease were divided into four groups： angina pectoris （AP 39）, acute myocardial infraction（AMI 32）, old myocardial infraction （OMI 22） and control group （30）. The levels of serum VEGF were measured by ELISA. [Results] The serum VEGF levels were higher in the AP, AMI and OIM patients than those of control group （P 〈0.01）, and higher in AMI patients than in AP patients （P 〈0.05）. There was no difference in VEGF levels between AMI and OIM patients （P 〉0.05）. The platelet levels in AMI patients were higher than those of the control group, AP and OIM （P〈0.01, P 〈0.01, P 〈0.05）. [Conclusion] Determination of serum VEGF and platelet levels may be useful for prognosis of patients with coronary heart disease, especially AMI patients.

关 键 词：心绞痛 急性心肌梗死 陈旧性心肌梗死 VEGF 血小板 

分 类 号：R446.6[医药卫生—诊断学]