心房颤动犬心房组织炎症因子的表达及意义  

Study on expression and significance of inflammatory factors in dog atria with atrial fibrillation

作　　者：董蕾[1,2] 刘元生[3] 李燕[5] 郭继鸿[4] 

机构地区：[1]北京市第六医院心内科,100007 [2]北京大学人民医院内科 [3]北京大学人民医院急诊科 [4]北京大学人民医院心内科 [5]山西医科大学附属第二医院急诊科

出　　处：《中国综合临床》2008年第7期628-630,共3页Clinical Medicine of China

基　　金：基金项目：国家自然科学基金资助项目（30271431）;北京市自然科学基金资助项目（7032030）

摘　　要：目的探讨炎症因子白细胞介素-1β（IL-1β）、C-反应蛋白（CRP）在心房颤动（房颤）时的表达及意义。方法健康杂种犬16条，随机分为对照组（n=8）和房颤组（n=8）。房颤组置入永久起搏器，起搏时间24周，制备房颤犬模型，对照组不置入起搏器。在左、右心房切取组织块，甲醛固定后石蜡包埋保存。两组石蜡切片均行免疫组织化学检测IL-1β和CRP，比较两组间IL-1β、CRP的表达水平。以平均吸光度表示各组IL-1β、CRP的表达水平，进行半定量分析。结果房颤组IL-1β及CRP的平均吸光度分别为（13．8±3．5）％、（13、4±2．8）％，均明显高于对照组[（11．1±3．8）％，（12．0±3.0）％]，均P〈0．05）。结论炎症因子IL-1β和CRP可能在房颤的发生和维持中起着促进的作用。Objective To investigate the expression and significance of interleukin-1β and C-reactive protein（ CRP） in atrial fibrillation（ AF）. Methods Sixteen mongrel dogs were randomly divided into two groups： pacing group （ n = 8 ） and control group （ n = 8 ）. High frequency pacing was performed in the pacing group with permanent pacemaker but not in the control group. After pacing for 24 weeks, tissue samples were obtained from the left and right atria. The levels of IL-1βand CRP in atria were detected by immunohistochemistry. Results Compared to the control group,the expression level of IL-1β and CRP were significantly enhanced （P 〈 0.05） in atrial tissues during AF. Conclusion IL-1β and CRP may participate in atrial fibrillation formation and play a role in generation and maintaining the artrial fibrillation.

关 键 词：心房颤动 白细胞介素-1Β C-反应蛋白 

分 类 号：R541.75[医药卫生—心血管疾病]