糖尿病肾病遗传易感性与血管紧张素转化酶2基因A9570G多态性的关系  

Association of the polymorphism of A9570G in ACE2 gene with the genetic predisposition of diabetic nephropathy

作　　者：陈文忠[1] 李志樑[1] 李明[2] 徐春生[3] 吴鹏[1] 

机构地区：[1]南方医科大学附属珠江医院心内科,广州510280 [2]南方医科大学附属珠江医院内分泌科,广州510280 [3]南方医科大学附属珠江医院急诊科,广州510280

出　　处：《中国综合临床》2008年第8期739-741,共3页Clinical Medicine of China

基　　金：基金项目：广东省自然科学基金资助项目（06301193）

摘　　要：目的研究血管紧张素转化酶2（ACE2）基因A9570G多态性与糖尿病肾病（DN）遗传易感性的关系。方法选择广东地区无血缘关系的2型糖尿病患者312例，其中并发DN154例，应用聚合酶链反应和限制性内切酶片段长度多态性的方法检测其ACE2基因A9570G多态性，综合分析ACE2基因A9570G多态性与DN的关系。结果男性糖尿病组G等位基因频率57．9％，DN组67．5％，差异无统计学意义（χ^2=1．559，P=0．212）；女性糖尿病组G等位基因频率52．4％，DN组52．1％，差异无统计学意义（χ^2=0．003，P=0．955）。女性糖尿病组与DN组基因型分布差异无统计学意义（χ^2=0．109，P=0．947）。结论ACE2基因A9750G多态性可能与DN遗传易感性无明显相关性。Objective To study the association of the polymorphism of A9570G in ACE2 gene with the genetic predisposition of diabetic nephropathy （ DN）. Methods 312 patients with type 2 diabetes（ T2DM ） were included in the study. All the patients were divided into DM group and DN group according to if onset of DN. PCRRFLP were used to observe the association of polymorphlsms of A9570G in ACE2 gene with DN. Results G allele frequencies of mate subjects were 57.9% in DM patients and 67.5% in DN patients （χ^2 = 1. 559 ,P = 0.2121,52. 4% and,52.1% in female DM and DN patients （χ^2 =0.003 ,P =0. 955 ）. In female patients,genetype in DN patients had no difference from that in DM patients （ χ^2 = 0. 109, P = 0. 947 ）. Conclusion The polymorphism of A9570G in ACE2 gene may not associated with the genetic predisposition of DN.

关 键 词：糖尿病肾病 血管紧张素转化酶2 基因 多态性 A9570G 遗传易感性 

分 类 号：R587.2[医药卫生—内分泌]