老年冠心病合并原发性高血压及2型糖尿病患者炎症与血栓前状态的相关研究  

The study of the relationship of the condition of inflammation and prethrombotic state in coronary heart disease complicated with essential hypertension and/or type 2 diabetes mellitus

作　　者：夏静[1] 李结华[1] 唐海沁[1] 

机构地区：[1]安徽医科大学第一附属医院干部心内科,合肥230022

出　　处：《中国综合临床》2008年第8期765-767,共3页Clinical Medicine of China

基　　金：基金项目：安徽省教育厅自然科学基金资助课题（2006KJ374B）

摘　　要：目的探讨老年冠心病（CHD）与合并原发性高血压（EH）和／或2型糖尿病患者体内炎症及血栓前状态的变化。方法CHD合并EH患者86例、合并2型糖尿病患者84例、合并EH及2型糖尿病患者80例、单纯CHD患者91例，健康体检者79例，分别检测其血清超敏C-反应蛋白（hs-CRP）、D-二聚体、血管性假血友病因子（VWF）浓度，并分析其相关性。结果与健康对照组比较，各组患者血清hs-CRP、D-二聚体、VWF均升高，高密度脂蛋白胆固醇（HDL-C）均降低（均P〈0．05），且CHD合并EH及2型糖尿病组患者hs-CRP、D-二聚体、VWF水平高于单纯CHD组、CHD合并EH组、CHD合并2型糖尿病组（均P〈0．05），差异具有统计学意义；多因素分析示单纯CHD组患者血清hs-CRP与D-二聚体、VWF呈正相关（均P〈0．05）。结论CHD同时合并EH及2型糖尿病的患者体内炎症及高凝状态更显著，检测其血清hs-CRP、D-二聚体、VWF对临床治疗具有指导意义。Objective To investigate the condition of inflammation and prethrombotic state （PTS） of the aged patients with coronary heart disease（CHD） complicated with esstential hypertension（EH） and type 2 diabetes mellitus （ T2DM ）. Methods The levels of fasting plasma hs-CRP, D-D and VWF were all measured in 86 CHD patients with EH ,84 patients with T2DM,80 patients with EH and T2DM,91 CHD patients and 79 normal cases. Resuits Compared with normal group, diseases groups had significantly higher hs-CRP, D-D, and VWF, but compared with CHD with EH and T2DM group, other diseases groups had lower hs-CRP, D-D and VWF（P 〈 0.05） ;The concentration of serum hs-CRP was positively correlated with D-D and VWF in CHD group （ P 〈 0.05 ）. Conclusion The inflammation and hypercoagulable state is more significant in CHD patients with EH and T2DM, thus the levels of plasma hs-CRP, D-D and VWF play an important role in the treatment.

关 键 词：冠状动脉疾病 原发性高血压 2型糖尿病 C-反应蛋白 血栓前状态 

分 类 号：R541.4[医药卫生—心血管疾病]