子痫前期及子痫患者GPⅡb/Ⅲa与PLT关系及临床意义  

Relation of the GPⅡb/Ⅲa and PLT in patients with pre-eclampsia or eclampsia and its clinical significance

作　　者：廖琪[1] 马晓艳[1] 刘超[1] 郑明阳[1] 李海霞[1] 苏学金[1] 

机构地区：[1]吉林大学第二医院妇产科

出　　处：《中国妇幼保健》2008年第22期3163-3165,共3页Maternal and Child Health Care of China

摘　　要：目的:检测子痫前期及子痫患者全血中GPⅡb/Ⅲa和血浆PLT水平,以探讨血小板活化因子在子痫前期、子痫的发生发展中的作用。方法:分别采用流式细胞术和全自动血细胞计数分析仪,检测子痫前期及子痫、正常孕晚期、正常未孕妇女全血GPⅡb/Ⅲa和血浆PLT水平。结果:全血中GPⅡb/Ⅲa水平:分娩前轻度子痫前期组(0.49±0.16)与正常未孕组(0.46±0.12)、正常孕晚期组(0.54±0.19)相比无明显差异(P>0.05);重度子痫前期及子痫组(2.60±0.63)与正常未孕组、正常孕晚期组、轻度子痫前期组比较有极显著差异(P<0.01)。分娩后各组之间均无显著差异(P>0.05)。重度子痫前期及子痫组分娩前后GPⅡb/Ⅲa比较,有极显著差异(P<0.01)。PLT计数:分娩前轻度子痫前期组(210.43±69.58)与正常未孕组(232.16±39.47)、正常孕晚期组(218.45±53.12)相比,无明显差异(P>0.05);重度子痫前期及子痫组(154.19±57.61)比正常未孕组、正常孕晚期组、轻度子痫前期组明显降低,有显著差异(P<0.05)。结论:重度子痫前期及子痫患者的GPⅡb/Ⅲa和PLT呈负相关性,这种关系变化是诊断子痫前期及子痫患者病情加重恶化的重要标志之一。Objective： To detected the levels of the GP Ⅱb/Ⅲa in the blood and PLT in the serum of the patients of pre - eclampsia and eclampsia, to discuses the role of platelet - active factors in the development of pre - eclampsia and eclampsiv. Methods： GP Ⅱb/Ⅲa and PLT were measured in the normal non - pregnancy women, normal late - pregnancy women and pre - eclampsia and eclampsia women. The GP Ⅱb/Ⅲa of whole blood was detected by flow cytometry and the levels of PLT in the serum were detected by blood cell analyst. Results： The levels of GP Ⅱb/Ⅲa in the mild pre - eclampsia （ 0. 49 ± 0. 16） and normal non - pregnancy （0. 46 ± 0. 12 ） or norreal late - pregnancy （0. 54 ± 0. 19 ） in pre - delivery had no significance （ P 〉 0. 05 ） . Severe pre - eclampsia/eclampsia in pregnancy （ 2. 60 ± 0. 63 ） was higher than non - pregnancy, normal late - pregnancy and mild pre - eclampsia （ P 〈 0. 01 ） . There was no significance between the groups in post -delivery. The GP Ⅱb/Ⅲa in severe pre- eclampsia/eclampsia had obvious changes in pre -delivery and post - delivery, the mild pre -eclampsia had no obvious change. The count of PLT： The mild pre -eclampsia （210.43 ± 69. 58 ） and normal non -pregnancy （232. 16 ± 39.47 ） or normal late -pregnancy （218.45 ± 53. 12） in pre -delivery had no obvious changes （P 〉 0.05 ）, but severe pre - eclampsia/eclampsia （ 154. 19 ± 57. 61 ） had obvious change （ P 〈 0. 05 ） . Conclusion： It shows significant negative correlation that the higher the level of GP Ⅱb/Ⅲa in the blood is, the lower the count of PLT in the blood serum is. This change of co - relationship is an important marker of the diagnoses.

关 键 词：血小板膜糖蛋白 纤维蛋白原受体 血小板 子痫前期 子痫 

分 类 号：R714.24[医药卫生—妇产科学]