联萘系列化合物在甘氨酸型手性固定相上的拆分  

Enantioseparation of Binaphthyl Compounds based on Phenylglycine Chiral Stationary Phase

作　　者：翁文[1] 范文静[1] 朱钦[1] 蔡剑霞[1] 姚碧霞[1] 

机构地区：[1]漳州师范学院化学与环境科学系,福建漳州363000

出　　处：《分析测试学报》2008年第7期721-724,共4页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(20705031);福建省自然科学基金资助项目(U0750017);福建省教育厅课题资助项目(JA05301)

摘　　要：探讨了7个联萘化合物在甘氨酸型手性固定相上的拆分,考察了流动相组成、柱温等对保留及手性拆分的影响,结合计算得到的热力学参数对手性识别机理进行了探讨。联萘酚及溴代联萘酚在该固定相上得到了良好的分离,其2个醚类衍生物得到了部分拆分,而3个酯类衍生物完全无法分离。拆分过程为焓驱动,酚羟基对提高二异构体与手性固定相之间的作用差异起关键作用。Enantioseparations of seven binaphthyl compounds based on phenylglycine chiral stationary phase,Chirex 3001,were studied.The effects of mobile phase composition and the column temperature on the retention and enantioseparation were discussed.The mechanism of chiral recognition was studied using the thermodynamic parameters.It was found that binaphthol and bromosubstituted binaphthol were well enantioseparated on the Chirex 3001 stationary phase,but two ether derivatives were only partially enantioseparated and the other three ester derivatives were no fully resolved.Results also indicated that the enantioseparations of these compounds were of an enthalpy-driven type.The phenol hydroxyl group was considered to play a key role in increasing the differenc of interaction between the two isomers and the chiral stationary phase.

关 键 词：液相色谱 手性拆分 手性识别 联萘 甘氨酸 

分 类 号：O657.72[理学—分析化学] TQ241.33[理学—化学]