前列安颗粒急性毒性与主要药效学研究  

Study on the Acute Toxicity and Main Therapeutic Effects of Qianliean Granules

作　　者：郭进[1] 刘灵改[1] 胡玉录[1] 戎成才[1] 周春华[1] 

机构地区：[1]河北医科大学第二医院药学部,石家庄050000

出　　处：《医药导报》2008年第8期928-930,共3页Herald of Medicine

基　　金：河北省科技攻关项目(基金编号:0427-6416)

摘　　要：目的考察前列安颗粒的急性毒性,验证其疗效,为临床安全用药提供依据。方法分别进行前列安颗粒急性毒性实验和主要药效学实验。考察前列安颗粒对1.5%角叉菜胶所致大鼠非细菌性前列腺炎的影响,对二甲苯所致小鼠耳肿胀的影响,0.6%醋酸所致小鼠腹腔毛细血管通透性的影响。结果急性毒性实验LD50无法测出,最大给药剂量为96 g.kg-1.d-1,相当于成人临床用量224.3倍。药效学实验表明,前列安颗粒可抑制角叉菜胶所致大鼠前列腺非细菌性炎症,增加前列腺组织内卵磷脂小体密度,并可明显抑制棉球肉芽肿形成;对二甲苯所致小鼠炎症均有明显抑制作用;可明显抑制0.6%醋酸所致小鼠腹腔毛细血管通透性增加。结论前列安颗粒临床用药安全,具有明显抑制前列腺炎作用。Objective To verify the curative effects of qianliean granules for providing the basis for its clinical use. Methods Acute toxicity and the main pharmacodynamics experiments were carried out. for exploring the influence of qianliean granules on non-bacterium prostatitis induced by 1.5% carrageenin on rats, ears swelling by dimethylbenzene and the change of abdominal capillary permeability causd by 0.6% acetic acid. Results LD50 wasn＇t able to be detected the largest tolerated dosage was 96 g · kg^-1· d^-1 , which was equal to 224.3 times of that for adults. Qianliean granules suppressed the inflammation caused by carrageenin, by increasing the density of lecithin inside prostate tissue, and the formation of granuloma. It also obviously inhibited the inflammation induced by dimethylbenzene. Qianliean granules significantly reversed the increase of capillary permeability by 0. 6% acetic acid. Conclusion Qianliean granules is safe for clinical application on inhibiting prostatitis.

关 键 词：前列安颗粒 前列腺炎 慢性 急性毒性 药效学 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]