老年人急性冠脉综合征(ACS)早期应用辛伐他汀的临床研究  

Application of simvastatin in old patient with acute coronary syndrome(ASC) in early stage.

作　　者：李晓明[1] 闫莉[1] 

机构地区：[1]四川省人民医院草堂医院内科,四川成都610072

出　　处：《四川医学》2008年第7期851-853,共3页Sichuan Medical Journal

摘　　要：目的观察评价了老年人ACS患者早期应用辛伐他汀调脂的疗效,6个月后随访结果。方法收集了我院首发住院的120例老年ACS患者,随机分成两组每组60例。入院后48h内治疗组给予辛伐他汀口服,对照组给安慰剂。服药后3、6个月评价患者血脂水平。随访6个月,观察两组患者心脑血管病事件的发生情况。结果辛伐他汀组治疗3个月TC、LDL-c、TG降低(P<0.05),6个月时降低较明显(P<0.01),TC下降29.1%,LDL-c下降26.2%,TG下降28.1%;HDL-c则升高6%(P<0.05);对照组无统计学差异。随访期心脑血管病事件中辛伐他汀组复发性心绞痛、心力衰竭、需再住院治疗心律失常发生率降低(P<0.05),而非致死性心肌梗死、脑卒中、心脏性死亡、非心脏性死亡的发生减少,差异无统计学意义(P>0.05)。结论老年人ACS患者应尽早应用他汀药物治疗,可获得明显的调脂疗效,改善患者的预后。Objective To investigate the efficacy of simvastatin for old patient with ACS in early stage.After 6 months made a follow-up visit the result.Methods To collect 12 examples old patient with ACS.Stochastically divides into two group of each group of 60 examples.In 48 hours after hospitalization to give simvastatin to take orall in simvastatin group.The comparison group gives the placebo.Takes medicine latter 3,6 months appraises the patients blood lipid levels.Makes a follow-up visit for 6 months.Observe two groups of patients in cardiovascular events.Results Simvastatin group to treat 3 months TC,LDL-c and TG have reduced.（P〈0.05） And 6 months reduces obviously（P〈0.01） TC drops 29.1%,LDL-c drops 26.2%,TG drops 28.1%;HDL-c elevates 6%（P〈0.05）.Comparison group have no statistics difference.Recurring angina pectoris,the heart failure,hospitalization again and arrhythmia of cardiovasvular events in simvastatin group have reduced.（P〈0.05）But non-lethal myocardial infarction,apoplexy,heart death and non-heart death have reduced and have no statistics significance.（P〉0.05）.Conclusion In old patients with ACS should apply simvastatin as soon as possible.This may obtains the obvious effect and improves patient＇s prognosis.

关 键 词：急性冠脉综合征 辛伐他汀 脂蛋白类 

分 类 号：R541.4[医药卫生—心血管疾病]