目安眼膏体外释药特性研究  

Drug Release Characteristics of Mu'an-Eye-Gel in Vitro

作　　者：何群[1] 吕毅[1] 张明亮[1] 张湘辉[1] 李希平[1] 

机构地区：[1]湖南中医药大学药学院,长沙市410007

出　　处：《中国药房》2008年第22期1700-1702,共3页China Pharmacy

基　　金：湖南省教育厅科学研究资助项目(99C99;05C380)

摘　　要：目的:比较我院自制的目安眼膏(阿昔洛韦+蜂蜜)与市售阿昔洛韦眼膏的体外释药特性。方法:将《中国药典》溶出度测定第三法与透析袋法相结合进行体外释药试验,运用紫外分光光度法测定2种制剂中阿昔洛韦含量以计算体外累积释药百分率,比较2种制剂的释药特征。结果:目安眼膏体外释放符合威布尔分布模型,而市售阿昔洛韦眼膏体外释放符合零级动力学模型,T80%分别为(3.156±0.013)、(10.16±0.009)h,Q8h分别为(93.28±0.010)%、(67.85±0.025)%,二者比较差异具有统计学意义。结论:目安眼膏释药速度及释药量均优于市售阿昔洛韦眼膏。OBJECTIVE： To compare home- made mu＇an- eye- gel（acyclovir plus honey） with commercial aciclovir （ACV） -eye- gel in releasing drug characteristics in vitro. METHODS： The in vitro drug release test was conducted by the third method of dissolution determination stated in Chinese Pharmacopeia together with bag filler method. The cumulative drug - releasing percentage and the acyclovir amount in mu＇ an - eye - gel versus ACV - eye - gel were determined by UV spectrophotometry, and the accumulative releasing drug percentages of the two preparations were computed and their drug release behaviors w ere compared. RESULTS ： The in vitro releasing behaviors of mu＇ an - eye - gel followed the Weibull kinetic equation, however the vitro releasing behavior of commercial ACV - eye - gel followed the zero order kinetic equation, and the T80% and Q8 h had statistical significances between（mu＇ an - eye - gel： T80% = 3.156 ± 0.013（h）, Q8 h = 93.28 ± 0.010（ % ） ; ACV - eye - gel ： T80% = 10.16± 0.009（h）, Q 8 h = 67.85 ± 0.025（ % ） ） 2 kinds of preparation. CONCLUSION ： Mu＇ an - eye - gel is superior to the commercial ACV ophthalmic gel in both releasing velocity and accumulative drug release percentage.

关 键 词：目安眼膏 阿昔洛韦眼膏 体外释放 累积释药百分率 

分 类 号：R988.1[医药卫生—药品] R978.7[医药卫生—药学]