阿克他利-羟丙基-β-环糊精包合物胶囊的制备及溶出度考察  

Preparation and Dissolution Rate of Inclusion Complex Capsules of Actarit-HP-β-CD

作　　者：张雯雯[1] 戴玉杰[1] 朱凌云[1] 

机构地区：[1]天津科技大学生物工程学院,天津市300457

出　　处：《中国药房》2008年第22期1725-1727,共3页China Pharmacy

摘　　要：目的:制备阿克他利-羟丙基-β-环糊精包合物胶囊,并考察其体外溶出性。方法:用搅拌法制备包合物,再分别以淀粉、微晶纤维素、乳糖、硫酸钙为填充剂制备包合物胶囊;采用转篮法对胶囊的溶出性进行考察,并与原料药及物理混合物比较。结果:与原料药及物理混合物比较,包合物的Td值更低(P<0.01);不同填充剂处方所制胶囊在15min内溶出均在75%以上。结论:阿克他利制成包合物后释放速度提高;4种填充剂所制包合物胶囊均能达到良好的溶出效果。OBJECTIVE ： To prepare the inclusion complex capsules of actarit - HP - β -CD and investigate their dissolution rate. METHODS： The inclusion complex was prepared by the stirring method with its dissolution rate investigated. The inclusion complex capsules were prepared with fillers consisted of starch, microcrystalline cellulose, lactose and calcium sulphate. The dissolution rate of the capsules was investigated by basket- stirring method and compared with those of the pure material and the physical mixture. RESULTS： Compared with pure material and physical mixture, the inclusion complex had significant lower value of Td （P〈0.01） . The dissolution rates of capsules with different formulations were all above 75% within 15 minute. CONCLUSION： The dissolution rate of inclusion complex was markedly increased and satisfactory dissolution efficacy was achieved in all the 4 capsules.

关 键 词：阿克他利 羟丙基-Β-环糊精 包合物 胶囊 溶出度 

分 类 号：R943[医药卫生—药剂学] R971.1[医药卫生—药学]