甲氨蝶呤热敏磁靶向脂质体的制备和靶向性研究  

Study of the preparation and targeting effect of methotrexate thermosensitive magnetoliposomes

作　　者：霍宗利[1] 朱林[2] 肖莹[1] 童昕[3] 倪坤仪[1] 

机构地区：[1]中国药科大学分析化学教研室,南京210009 [2]中国药科大学药剂教研室,南京210009 [3]南京市口腔医院种植中心,南京210008

出　　处：《海峡药学》2008年第7期14-17,共4页Strait Pharmaceutical Journal

摘　　要：采用正交设计以37℃和43℃释出的游离药物之比为评价指标优化甲氨蝶呤热敏磁靶向脂质体处方。并测定了小鼠尾静脉注射甲氨蝶呤溶液和甲氨蝶呤脂质体后,全血和肌肉中的药物浓度。结果表明,给予甲氨蝶呤脂质体后再外加磁场并置于43℃环境,脂质体靶向效率Te提高6.8倍,相对摄取量Re提高6.5倍。说明本实验制备的脂质体具有很高的靶向性。The formulation of the methotrexate thermosensitive magnetoliposomes was optimized by orthogonal design according to the ratio of drug release property of liposomes at 37℃ and 43℃ in vitro. And the targeting effect of methotrexate liposomes prepared under the optimum condition was studied by the determination of methotrexate in whole blood and muscles. The results indicated that the targeting effect （Te）of methotrexate lipo- somes increased 6.8 folds while the relative uptake effect （Re）increased 6.5 folds. It was shown that the methotrexate liposomes prepareded in this paper had high targeting effect.

关 键 词：甲氨蝶呤 热敏磁靶向脂质体 蚤黄卵磷脂 正交试验 

分 类 号：TQ460.4[化学工程—制药化工]