不同稀释浓度的奥美拉唑静脉滴注液稳定性研究  

Study of stability of omeprazole injection with different concentrations

作　　者：刘丽萍[1] 

机构地区：[1]安徽医科大学第一附属医院药剂科,安徽合肥230022

出　　处：《安徽医药》2008年第7期610-612,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的考察稀释成不同浓度的奥美拉唑溶液的稳定性。方法分别用0．9％氯化钠注射液和5％葡萄糖注射液将静脉滴注用奥美拉唑制剂（洛赛克和奥西康）稀释成0．08、0．16、0．4、0．8g·L^-1浓度的溶液，采用高效液相色谱法和pH值测定法于0、1、2、4、8h，测定奥美拉唑的含量和pH值。结果采用0．9％氯化钠注射液稀释的奥美拉唑制剂的pH值变化范围为8．32～9．84；采用5％葡萄糖注射液稀释奥美拉唑制剂的pH值变化范围为7．84～9．68，8h内所有样品含量无显著性变化。结论采用0．9％氯化钠注射液和5％葡萄糖注射液配制奥美拉唑静脉滴注液，在浓度大于0．08g·L^-1时，8h内溶液可保持稳定。Aim To study the stability of omeprazole injection with different concentrations. Method Omeprazole was diluted with 0. 9% sodium chloride injection and 5% glucose injection to the concentration of 0.08,0.16,0.4 and 0.8 g · L^-1. The content and pH value of omeprazole were determined at 0,1,2,4 and 8 h. Result The pH value was 8.32 - 9.84 and 7.84 - 9.68 diluted with 0.9% sodium chloride injection and 5% glucose injection respectively, and no significant variation of content as found in experimental time. Conclusion Omeprazole solution which was diluted with 0.9% sodium chloride injection and 5% glucose injection can be stable in 8 hours when the content is more than 0.08 g · L^-1.

关 键 词：奥美拉唑溶液 PH值 含量 稳定性 

分 类 号：R927[医药卫生—药学]