根皮素抑制肝癌细胞恶性表型的研究  

Study on the Effect of Phloretin on Inhibiting Malignant Pheotype of BEL-7402 Cells

作　　者：罗辉[1] 汪亚君[2] 陈杰[2] 刘江琴[1] 

机构地区：[1]广东医学院化学教研室,广东湛江524023 [2]广东医学院生物化学与分子生物学教研室,广东湛江524023

出　　处：《中药材》2008年第7期1019-1021,共3页Journal of Chinese Medicinal Materials

基　　金：广东省科技计划项目(2006B14701008)

摘　　要：目的:探讨根皮素对肝癌BEL-7402细胞株运动、侵袭、粘附、克隆形成率的影响。方法:MTT法和Costar Transwell检测根皮素抑制BEL-7402细胞的增殖、运动、侵袭、粘附、克隆形成率。结果:根皮素能抑制BEL-7402细胞的增殖、侵袭、运动、粘附及克隆形成能力,并呈现出剂量依赖性。结论:根皮素能抑制BEL-7402细胞的恶性表型。Objective：To investigate the effect of phloretin on inhibiting BEL-7402 cells′ growth,invasive,migration and adhesion ability and the rate of colony formation.Methods：BEL-7402 cells′ growth,invasive,migration and adhesion ability and the rate of colony formation were examined with MTT method and Costar Transwell.Results：Phloretin inhibited the growth,invasive,migration and adhesion ability of BEL-7402 cells and reduced the rate of colony formation in dose-dependent.Conclusion：Phloretin can inhibit BEL-7402 cells′ malignant pheotype.

关 键 词：根皮素 转移 肝癌 

分 类 号：R285.5[医药卫生—中药学]