几种新型Schiff碱衍生物抗菌活性的测定  

Detection of antibacterial activity of some new Schiffbase derivative

作　　者：李淑荣[1] 金树兴[2] 谢阳 刘蒲[4] 

机构地区：[1]郑州大学药学院,郑州450001 [2]郑州大学实验动物中心,郑州450052 [3]河南省直属机关第一医院急诊科,郑州450000 [4]郑州大学化学学院,郑州450001

出　　处：《郑州大学学报（医学版）》2008年第4期787-789,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:对6种Schiff碱衍生物抗菌活性进行测定。方法:利用氨基葡萄糖与苯甲醛及其衍生物在甲醇溶剂中回流,合成了6种新的Schiff碱衍生物;通过悬菌定量法测定其抗菌活性。结果:6种Schiff衍生物a、b、c、d、e、f对大肠杆菌15min杀灭率分别达到(69.91±8.36)%、(99.16±3.46)%、(99.29±1.35)%,(98.67±5.34)%、(78.50±7.85%)、(62.63±7.12)%。结论:该6种化合物的抗菌效果不同。Aim ：To observe the antibacterial activity of 6 kinds of new Schiff base derivative. Methods ： Glucosamine with substituted benzaldehydes were under reflux in methanol tosynthesis 6 new Schiff-bases. There antimicrobial activity was examined against E. coil by quantitative suspension method. ReSUltS ：The inhibitory ratio to E. coil is of a, b, c, d, e, f were （69.91 ±8.36）% , （99. 16 ± 3.46）% , （99.29 ± 1.35）%, （98.67 ± 5.34）% , （78.50 ± 7.85 ）% , （62.63 ± 7.12） % ,respectively. Conclusion：The obtained new Schiff-bases derivative are inhibitory to the growth of E. coil.

关 键 词：氨基葡萄糖 Schiff碱衍生物 抗菌活性 

分 类 号：R978.1[医药卫生—药品]