戒烟治疗中的药物疗法研究进展  

A Review of Pharmacotherapy for Treating Tobacoo Use and Dependence

作　　者：周岩[1] 贺加[1] 

机构地区：[1]第三军医大学社会医学与卫生事业管理教研室,重庆400038

出　　处：《医学与哲学（B）》2008年第7期49-50,63,共3页Medicine & Philosophy(B)

摘　　要：停止尼古丁摄入造成的戒断症状是每个戒烟者都要面对的困难。我国的吸烟者很少采用戒烟药物作为辅助,而且国内目前尚无戒烟药物的临床应用研究。本文旨在向国内的医务工作者介绍国外近年来戒烟药物在临床应用的概况,给有戒烟打算的吸烟者提供有效的药物治疗方案。目前国外的研究均肯定了尼古丁替代制剂和盐酸安非他酮缓释片在戒烟治疗中的疗效,且治疗1年后的随访结果显示,这两种药物均能有效提高戒烟率。使用盐酸安非他酮缓释片的效果稍好一些,可能与避免尼古丁替代制剂继续维持戒烟者的尼古丁依赖有关。由盐酸安非他酮缓释片存在不良反应和安全性的问题,在临床应用时多采用两者联用的方法,以求最大程度增加戒烟成功率。Nicotine dependence develops among smokers, and they exhibit withdrawal symptoms when they try to stop smoking. Few national smokers who want to quit use pharmacotherapy against abstinence symptoms. We conducted a review of published reports of smoking cessation pharmacotherapy trials in order to address the following： i. Research findings suggest that these medications are safe and effective; ii. Recent survey suggest that Sustained--Release Bupropion does better work than Nicotine--replacement since it is likely that long duration of Nicotine--replacement may maintain nicotine dependent; iii. The use of two or more products may be necessary in clinical practice.

关 键 词：尼古丁替代疗法 盐酸安非他酮缓释片 戒烟 

分 类 号：R453[医药卫生—治疗学]