2,2-二氯-1(4-乙氧基苯基)环丙烷甲酰胺类衍生物的合成及生物活性  

Synthesis and biological activity study of 2,2-dichloro-1(4-ethoxyphenyl) cyclopropanecarboxamide derivatives

作　　者：傅昊[1] 孙娜波[1] 沈德隆[1] 丛杉[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,浙江杭州310032

出　　处：《浙江工业大学学报》2008年第4期412-415,422,共5页Journal of Zhejiang University of Technology

摘　　要：以1-对乙氧基苯基-2,2-二氯环丙烷甲酸为起始原料,通过酰氯化、胺基化反应,设计并合成了6个1-对乙氧基苯基-2,2-二氯环丙烷甲酸衍生物,其结构均经IR,1H NMR,MS进行表征.初步的生物活性测定结果表明,该类化合物具有一定的杀虫、抑菌活性.其中化合物SI-4-2和SI-4-5在500 mg/L时对粘虫的致死率分别为48.5%和36.1%.SI-4-1的杀菌活性最好,在200 mg/L时,对黄瓜灰霉病菌的抑制率为61.2%.Six of 2, 2-dichloro-1 （4-ethoxyphenyl） cyclopropanecarboxylic acid Derivatives Containing Phenyl were designed and synthesized from 2, 2-dichloro-1 （4-ethoxyphenyl） cyclopropanecarboxylic acid by the acylation and amidogen reactions. The structures of the products were characterized by IR, 1H NMR, MS. The results of preliminary bioassays showed that some compounds exhibited certain insecticidal and antibact -erial activities. The mortalit of SI-4-2 and SI-4-5 to Mythimnaseparate reached 48.50/00 and 36.1% at 500 mg/L. The inhibition of SI-4-1 to Botrytiscinerea reached 61.2%.

关 键 词：1-对乙氧基苯基-2 2-二氯环丙烷甲酸 合成 生物活性 酰胺 

分 类 号：O624.6[理学—有机化学]