临床用药对不稳定型心绞痛患者脂联素和相关指标的影响  

Effect of clinical medication on serum adiponectin and correlated indices in patients with unstable angina

作　　者：钟毓琼[1] 陈玲[2] 梁淑连[1] 易伟莲[3] 

机构地区：[1]广东医学院第二附属医院检验科,广东湛江524023 [2]广东医学院第二附属医院心内科,广东湛江524023 [3]广东医学院附属医院检验科

出　　处：《检验医学与临床》2008年第16期967-969,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨阿托伐他汀对不稳定型心绞痛(UAP)患者脂联素以及其他炎性指标的影响。方法48例UAP患者随机分成常规组和阿托伐他汀组,常规组使用常规药物治疗,阿托伐他汀组在常规治疗基础上加用阿托伐他汀20mg/d,均治疗2周,分别于治疗前和治疗后2周抽血测定脂联素及其他相关指标。同时设45例健康人群作为健康对照组。结果与健康对照组相比,UAP患者的血清脂联素显著降低,而炎性反应因子超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)显著升高。治疗后阿托伐他汀组和常规组hs-CRP、TNF-α、IL-6均下降,但阿托伐他汀组治疗后较常规组明显下降(P<0.05)。阿托伐他汀组治疗后血清脂联素明显升高。结论阿托伐他汀治疗能降低UAP患者hs-CRP、TNF-α、IL-6水平,有助于纠正UAP患者的炎性反应因子水平。Objective To investigate the effect of atorvastatin on serum adiponectin and other inflammatory indices in patients with unstable angina. Methods Forty-eight patients with unstable angina were randomly divided into two groups., convention group （treated with conventional therapeutic drugs） and atorvastatin group （besides conventional therapeutic drugs, given atorvastatin 20 mg per day for two weeks）. Serum adiponectin and correlated indices were measured before and after 2 weeks＇ intervention. Forty-five healthy people were enrolled as controls （control group）. Results Compared with those of healthy controls, serum adiponectin levels in UAP patients were significantly lower （P〈0.01） and levels of hs-CRP, TNF-α and IL-6 were higher （P〈0.05）. After 2 weeks of treatment, the levels of hs-CRP, TNF-α and IL-6 were decreased in both convention group and atorvastatin group, but the levels of above indices were more declined in atorvastatin group. The patients in atorvastatin group had lower levels of hs-CRP, TNF-α and IL-6 and higher levels of serum adiponectin compared with control group （P〈0.05）. Conclusion Atorvastatin can decrease the levels of hs-CRP, TNF-α and IL-6 in UAP patients, which exerts beneficial effects on the above inflammatory factors.

关 键 词：不稳定型心绞痛 阿托伐他汀 脂联素 超敏C反应蛋白 

分 类 号：R446.1[医药卫生—诊断学] R972.3[医药卫生—临床医学]