人免疫缺陷病毒感染与血栓形成性疾病  

Human Immunodeficiency Virus Infection and Thrombotic Diseases

作　　者：杨咏梅[1] 艾清龙[1] 

机构地区：[1]昆明医学院第一附属医院神经内科,650032

出　　处：《国际脑血管病杂志》2008年第6期464-468,共5页International Journal of Cerebrovascular Diseases

摘　　要：人免疫缺陷病毒（HIV）感染者血液中可出现抗磷脂抗体、狼疮抗凝物，von Willcbrand因子、D-二聚体水平升高，蛋白S、蛋白C、抗血栓素和肝素辅因子减少，从而导致血液高凝状态。此外，HIV感染本身及继发性机会性感染也可使血管内皮受损。血液高凝状态和血管内皮损伤均可促使血栓形成性疾病的发生。Anti-phospholipid antibody and lupus anticoagulant appear in the blood of patients with human immunodeficiency virus （HIV） infection, which result in the increased levels of yon Willebrand factor and D-dimer, and decreased the levels of protein S, protein C, antithrombin and heparin cofactor, and thus result in hypercoagulation status. In addition, the HIV infection itself and secondary opportunistic infections may also cause endothelial injury. Both hypercoagulation status and endothelial injury may promote the occurrence of thrombotic diseases.

关 键 词：人免疫缺陷病毒 获得性免疫缺陷综合征 血栓形成 

分 类 号：R593[医药卫生—内科学] R51[医药卫生—临床医学]