参麦注射液对蒽环类药物心肌毒性的治疗作用  

Protective effect of ShenMei injection on anthrocyclines cardiotoxicity

作　　者：欧阳桂芳[1] 陈晓敏[1] 顾雪薇[1] 倪丽芬[1] 徐薇[1] 罗敏[1] 黄道德 倪晶晶 黄英杰[3] 

机构地区：[1]宁波市第一医院,315010 [2]宁波卫生学校 [3]海军412医院

出　　处：《宁波医学》1997年第3期105-107,共3页

摘　　要：给家免耳静脉注射阿克拉霉素（ACM），病理证实能产生心肌病变，成功地建立了蒽环类药物致心肌损害的动物模型。实验将家兔分为：①正常对照组，注入生理盐水。②治疗组，注入ACM＋参麦注射液。③对照组，注入ACM＋生理盐水。实验第20天测血心肌酶谱（CK、CK－MB、AST、LDH），心肌标本在光镜下进行检查。结果显示：治疗组家兔CK、CK－MB显著低于对照组（t(cK-MB)＝3.155，t(CK)＝244，P＜005～0.01），光镜下心肌病理改变，治疗组显著轻于对照组（P＜0.05～0.01）。实验结果表明参麦注射液能治疗蒽环类药物导致的心肌毒性。Myocardial lesion could be developed in rabbits by injection with aclamycin(ACM) and then an experimental animal modelwas successfully established. All rabbits were divided into (1)Normal control group, each rabbit was injected with normal saline solution. (2) Therapeutical group, ACM and ShenMei injection was administrated per day for ten days. (3) Control group, rabbits were injected with normal saline solution after injection of ACM. Activity of serum CK, CK-MB, LDH,AST were detected and myocardial specimens were examinedunder conventional light microscope on the 20th day. Result showed that activities of CK, CK - MB in therapeutical group were significantly lower than in control group on the 20th day (t=3. 155, t= 2. 44, P < 0. 05 - 0. 01); under light microscope histolyical abnormalities of myocardium in control group was worse than in therapeutical group on the 20th day (P < 0.01). It suggested that ShenMei injection may have some therapeutical effect on anthracyclines cardiotoxicity in rabbit.

关 键 词：心肌毒性 蒽环类药 动物模型 参麦注射液 中药品 

分 类 号：R259.422[医药卫生—中西医结合] R286[医药卫生—中医内科学]