青岛地区汉族人群杀伤细胞免疫球蛋白样受体基因多态性研究  

The distribution of killer immunoglobulin-like receptor genes in Qingdao Han population

作　　者：李长缨 胡彬 王同显 刘棋 纪玉强[2] 焦淑贤 赵林 

机构地区：[1]青岛市中心血站,山东青岛266071 [2]西安交通大学

出　　处：《中国输血杂志》2008年第7期506-508,共3页Chinese Journal of Blood Transfusion

基　　金：青岛市2006医疗卫生科技计划项目(编号:KZzd-72)

摘　　要：目的了解青岛地区汉人群杀伤细胞免疫球蛋白样受体(K IR)基因分布多态性及其与其他人群的差异。方法采用序列特异性引物聚合酶链反应(SSP-PCR)对青岛地区汉族人群进行KIR基因进行分型检测,统计不同KIR基因在青岛地区汉人群中的检出频率及其与我国中部地区、南部地区和世界其它地区KIR基因分布的比较。结果在青岛地区汉人群中,该试剂可检测的14种KIR基因和2种假基因均可检测到并表现出不同的分布频率。结论该地区不同KIR基因的分布频率有很大差异。所有抑制性基因检出率均高于相应的活化性基因的检出率;我国南、北方汉人群中KIR基因分布频率差异很大,多种KIR基因的分布自南向北有渐增高的趋势;韩国和日本人群KIR基因分布频率与中国北方汉人相接近。Objective To investigate the distribution of killer immunoglobulin-like receptor（K/R） genes in Qingdao Han population and its difference from other populations. Methods The K/R genotypes of 81 cascs were examined by PCRSSP , and the gene frequencies were calculated and compared to those of other populations. Result Fourteen K/R genes and 2 pseudo genes were found and all had different gene frequencies. Conclusion All inhibit-gene frequencies are higher than their active-gene frequencies. K/R gene frequencies are different between the southern and northern Chinese Han people. Many of them increase gradually from the south to the north. The K/R gene distributions of Korean and Japanese populations are close to the Northern Chinese Han population.

关 键 词：杀伤细胞免疫球蛋白受体 基因分布 基因频率 

分 类 号：R392[医药卫生—免疫学] R457.13[医药卫生—基础医学]