安徽省肾综合征出血热Ⅰ型灭活疫苗中期流行病学效果考核  

Evaluation on the Middle-Term Epidemiological Efficacy of Type ⅠInactivated Vaccine against HFRS in Anhui Province

作　　者：罗兆庄[1] 刘红[1] 王以银[1] 任次早 宋明宇[2] 吴柄权 韩远荣 

机构地区：[1]安徽省卫生防疫站,合肥230061 [2]霍邱县卫生防疫站 [3]颖上县卫生防疫站 [4]六安市卫生防疫站

出　　处：《中国媒介生物学及控制杂志》1997年第5期336-339,共4页Chinese Journal of Vector Biology and Control

摘　　要：观察沙鼠肾细胞Ⅰ型灭活疫苗的中期流行病学效果。方法：采用间接免疫荧光抗体法（IFA）、微量细胞变性中和试验（MCPENT），分别检测荧光抗体及中和抗体；调查接种组与对照组人群发病情况。结果：自1994年10月以来的两年中，接种组发病1例（轻型），发病率为9．27／10万；对照组发病问例，发病率为161.98／10万，保护率为94．28％。流行高峰前（1996年10月）、后（1997年3月）新出现荧光抗体阳性4人，均无任何临床表现。结论：该疫苗有良好的中期防病效果；接种人群不存在免疫增强现象。From October 1994 2 years' observation op the population innoculated with tyPe Ⅰinactivated vaccine (prepared from tissue culture of Mongolian gerbils kidney supplied by Institute of Biological Products, shanghai) showed that there was 1 case in the innoculated group, the morbidity rate was 9. 27/100 000, 17 cases in the control group, the morbidity rate was 16. 198/ 100 000 and the protection rate was 94. 28 %. The results indicated that the middle-term protection efficacy of the vaccine be sound.The case in the innoculated group was a patient of light-tyPe spoptom. Before epidemic peak (in October 1996) and after epidemic peak (in March 1997), 4 of the innoculated population had seroconversion of immunofluorescent antibody by IFA, but they had no clinical symptom. These showed that the vaccine didn't cause antibody dependent immunization enhancement.

关 键 词：肾综合征出血热 灭活疫苗 流行病学效果 

分 类 号：R512.803[医药卫生—内科学]