肾综合征出血热地鼠肾细胞Ⅱ型灭活疫苗的安全性、免疫性及其流行病学效果考核  

Evaluation on the Safety and Immunological Effect of Type Ⅱ Inactivated Vaccine against HFRS Prepared from Tissure of Hamster Kidney and Study on its Epidemiological Efficacy

作　　者：罗兆庄[1] 刘红[1] 俞正楚[1] 王以银[1] 任次早 徐立[2] 张大荣[1] 李德琴 

机构地区：[1]安徽省卫生防疫站,合肥230061 [2]安庆市卫生防疫站 [3]广德县卫生防疫站

出　　处：《中国媒介生物学及控制杂志》1997年第5期339-341,共3页Chinese Journal of Vector Biology and Control

摘　　要：目的：考核HFRS地鼠肾细胞Ⅱ型灭活疫苗的安全性、免疫法及其流行病学效果。方法：采用间接免疫荧光抗体试验（IFA）、微量细胞变性中和试验（MCPENT），检测接种者血中荧光抗体及中和抗体水平；调查接种组与对照组发病情况。结果：以怀宁、广德两县18个村为疫苗观察现场，接种组7499人，对照组7261人，中强反应率为224％（5／223）。3针全程免疫后中和抗体阳转率为63．33％（19／30），荧光抗体阳转率为38.58％（27／70）；接种后1年内接种组无发病，对照组发病3例。结论：该疫苗的安全性较好；有一定水平的免疫应答，但防病效果应进一步观察确证。The obsevation was carried out in 18 villages in Huaining and Guangde. There were 7499inhabitants in the inoculation group and 7261 in the contro group. The rate of rnedium and strong response was 2. 24 % (5/223). After 3 doses of injection, the rate of seroconversion of neutralising antibody was 63. 33 % (19/30) and that of immunonuorescent antithey was 38. 58% (27/70). In 1 year after the whole course of immunization, no patient was found in the inoculation group, while 3 patients were found in the control group.

关 键 词：肾综合征出血热 灭活疫苗 免疫性 流行病学效果 

分 类 号：R512.803[医药卫生—内科学]