肾综合征出血热Ⅰ型灭活疫苗加强免疫后抗体反应及流行病学效果  

Study on Antibody Reaction and Epidemiological Effect after Reinforcement of Type ⅠInactivatcd Vaccines against HFRS

作　　者：张军[1] 童政 周联娣[1] 赵守军[1] 叶克龙 徐志一[1] 

机构地区：[1]上海医科大学流行病学教研室,200032 [2]浙江省建德市卫生防疫站

出　　处：《中国媒介生物学及控制杂志》1997年第5期342-344,共3页Chinese Journal of Vector Biology and Control

摘　　要：目的：观察HFRS沙鼠肾灭活疫苗（Ⅰ型）加强免疫后的血清学效果及防病效果。方法：采用间接免疫荧光试验和双夹心ELISA法，检测血清中的IgG抗体；以微量细胞病变中和试验，检测血清中的中和抗体。结果：加强免疫前，血清抗体阳性率仅为18．3％，中和抗体阳性率为0％；加强免疫后2周，抗体阳性率升至90.1％，中和抗体阳性率达75％。加强免疫后1年内，接种组无1例病人发生，而未接种者发病5例。Obective: The purpose of this report was to observe the serofogic and preventive effect of TyPe Ⅰinactivated vaccines against HFRS (prepared from tissue culture of Mongoian gerbils kidney)after rein forcement. Methods: Indirect immunofluorescent antibody methed and Enzyme-linked Immunosorbent Assay indirect sandwich method were used in testing IgG antibody in sera. Microcytopathic effect neutralization test was used in the detection of neutralizing antithey in sera. Results: Before reinforcement, the Positive rate of antithey in sera was 18. 3 %, and that of neutralization antithey was 0 %.2 weeks after reinforcement, the POsitive rate of antibody in sera was 90. 1 %, and that of nentralization antibody was 75 %. 1 year after reinforcernent, there was no patient found in the inoculation group, and there were 5 patients found in the control group.

关 键 词：肾综合征出血热 灭活疫苗 流行病学效果 

分 类 号：R512.803[医药卫生—内科学]