β-四(4-羧基苯氧基)酞菁锌的合成与抗肿瘤活性研究  

Study on Synthesis and Antineoplastic Activity of β-tetra-(p-carboxyphenoxy) phthalocyanine Zinc

作　　者：邸凯[1] 陈伟[1] 李涛[2] 王玉[2] 李晓丽[1] 夏春辉[2] 

机构地区：[1]齐齐哈尔大学化学化工学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院,黑龙江齐齐哈尔161042

出　　处：《信阳师范学院学报（自然科学版）》2008年第3期439-441,共3页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：黑龙江省教育厅科学技术研究项目(11511441);黑龙江省齐齐哈尔市重点科技项目(GY05-19,SFG06-02);黑龙江省卫生厅科学技术研究项目(2005-333)

摘　　要：通过两步合成了两亲性的β-四(4-羧基苯氧基)酞菁锌(Ⅱ),采用UV-Vis、IR、元素分析、激光解吸电离飞行时间质谱(TOF-MS)对配合物进行了表征.在光诱导条件下,采用四甲基偶氮唑蓝比色法(MTT法),研究了此酞菁锌配合物对Bel-7402细胞抑制作用,考察了浓度对配合物的抑瘤效果的影响,确定其IC50值,结果发现:在光诱导条件下,酞菁锌配合物的适宜浓度具有较高的抑制率,并探讨了其抑瘤机理.A novel water soluble β-tetra-（p-earbexyphenoxy） phthalocyanine zinc （ Ⅱ ） has been synthesized in two-step. It was characterized by UV-vis absorption spectrum, IR spectrum, elemental analysis and TOF-MS. The damaging effects of phthalocyanine eomplexe on human Bel-7402 liver cancer cell were investigated by means of HE dye method and MTT eolorimetrie assay under photoinduee. The influences of the concentration of phthalocyanine complex on cancer inhibition were systemically studied and IC50 value was ascertained. The results show that this phthaloeyanine zinc complex exhibits good inhibition effects in appropriate concentration, and the inhibition mechanism was primarily discussed.

关 键 词：酞菁锌 光诱导杀伤 BEL-7402细胞 

分 类 号：O644.12[理学—物理化学] R735.7[理学—化学]