强化降糖治疗2型糖尿病合并阻塞性睡眠呼吸暂停综合征患者的疗效观察  

Intensive Blood Glucose Control in Type 2 Diabetes Mellitus Combined with Obstructive Sleep Apnea Syndrome

作　　者：杨欢[1] 赵文穗[1] 张如根[1] 

机构地区：[1]上海市长宁区中心医院内分泌科,200336

出　　处：《中国全科医学》2008年第16期1477-1478,1481,共3页Chinese General Practice

基　　金：上海市长宁区局级青年课题资助项目(20054Q01001)

摘　　要：目的观察强化降糖治疗2型糖尿病合并阻塞性睡眠呼吸暂停综合征(OSAS)患者的疗效。方法将57例2糖尿病合并OSAS患者随机分为强化治疗组和常规治疗组,前者给予胰岛素强化治疗,后者给予常规药物治疗。治疗前及治疗4周后进行多导睡眠仪检查,观察治疗前后两组患者呼吸紊乱指标的变化。结果强化治疗组患者治疗后呼吸暂停指数和紊乱指数与治疗前比较,差别有统计学意义(P<0.01)。强化治疗组中,BMI<25 kg/m2的患者治疗前后暂停指数和紊乱指数差值与BMI≥25 kg/m2的患者比较,差别有统计学意义(P<0.05)。结论强化降糖治疗对于2型糖尿病合并OSAS的患者有一定疗效,能改善呼吸暂停指数及紊乱指数,对于超重患者效果更好。Objective To observe the effect of intensive blood glucose control in type 2 diabetic mellitus （T2DM） combined with obstructive sleep apnea syndrome （OSAS）. Methods Fifty - seven patients with T2DM with OSAS were divided into two groups： intensive treatment group （group A） and conventional treatment group （group B）. Group A were treated with intensive insulin and Group B with conventional drugs. They were examined with multilead sleep detector before treatment and 4 weeks after treatment, to analyze the changes of various parameters of respiratory disturbance （RD）. Results After 4 weeks treatment, there was significant improvement in activity apnea - hypopnea index （AHI） in Group A （ P 〈 0. 01 ）, but no changes were found in Group B （ P 〉 0. 05）. Conclusion Intensive blood glucose control has some effects on T2DM with OSAS, it can improve AHI and RDI, especially in overweight patients.

关 键 词：糖尿病 2型 胰岛素 睡眠呼吸暂停 阻塞性 

分 类 号：R587.1[医药卫生—内分泌] R765.2[医药卫生—内科学]