非高密度脂蛋白胆固醇与睡眠呼吸暂停低通气综合征合并冠心病的相关性  

Changes of Non-high-density Lipoprotein Cholesteral in Patients with Obstructive Sleep Apnea Hypopnea Syndrome Accompanied by Coronary Heart Disease

作　　者：孙依萍[1] 任涟萍[1] 郭雪君[1] 

机构地区：[1]上海交通大学医学院附属新华医院呼吸内科,上海市200092

出　　处：《中国全科医学》2008年第16期1494-1495,共2页Chinese General Practice

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并冠心病患者与单纯OSAHS患者血脂水平的差异。方法选取我院收治的31例OSAHS合并冠心病患者(OSAHS合并冠心病组)和39例单纯OSAHS患者(单纯OSAHS组),均经多导睡眠监测仪(PSG)检查,测定呼吸暂停低通气指数(AHI)、最低血氧饱和度(SaO2)及空腹血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及非高密度脂蛋白胆固醇(n-HDL-C)水平,比较两组间的差异。结果两组患者n-HDL-C水平间差异有统计学意义(P<0.05),而总胆固醇、三酰甘油、HDL-C、LDL-C水平间差异无统计学意义(P>0.05)。结论OSAHS合并冠心病者较单纯OSAHS患者存在更为明显的脂质代谢异常,n-HDL-C可用于OSAHS患者合并冠心病风险的评估。Objective To investigate the differences of plasma lipid levels between obstructive sleep apnea hypopnea syndrome （OSAHS） patients with coronary heart disease （CHD） and those without. Methods Seventy OSAHS patients, 31 combined with CAD （ combined group） and 39 without （ simple group）, were enrolled, all of whom were examined by polysom- nography to detect the contents of apnea - hypopnea index （ AHI ）, minimum oxygen saturation （ SaO 2 ）, total cholesterol （TC）, triglyceride （TG）, high- density lipoprotein cholesterol （HDL- C）, low-density lipoprotein cholesterol （LDL- C） and non - high - density lipoprotein cholesterol （ n - HDL - C）, and to compare the differences between them. Results The contents of n - HDL - C were significantly higher in combined group than in simple group （ P 〈 0. 05 ）. There was no significant difference in TC, TG, HDL - C and LDL - C between the two （ P 〉 0. 05 ）. Conclusion OSAHS patients with CHD have more presence of abmormal lipid metabolism than those without. The level of n - HDL - C can be used to assess the incidence of CHD in OSAHS patients.

关 键 词：睡眠呼吸暂停综合征 冠状动脉疾病 非高密度脂蛋白胆固醇 

分 类 号：R56[医药卫生—呼吸系统] R543.3[医药卫生—内科学]